Anti-p27 Kip1 pAb

MBL Life Sciences

Background

Cyclin dependent kinase inhibitory protein 1 (Kip1) is a 27 kDa inducible inhibitor of cyclin-dependent kinase complexes (CKI). It acts by suppressing S-phase entry and thereby blocking cell cycle progression. Kip1 interacts strongly with D-type cyclins in complex with Cdk4 and weaklier with cyclin E/Cdk2 complex to cause G1 arrest. Kip1 is a potent tumor suppressor for multiple epithelially derived neoplasias, and expression of Kip1 is frequently down regulated in human tumors. Kip1 levels are regulated by phosphorylation and degradation via the ubiquitin-proteosome pathway.

 

Western Blotting

1. Takigami S et al. Projection pattern of vomeronasal neurons to the accessory olfactory bulb in goats. Chem Senses. 25, 387-393 (2000)(PMID:10944501)
2. Krsmanovic LZ et al. Muscarinic regulation of intracellular signaling and neurosecretion in gonadotropin-releasing hormone neurons. Endocrinology. 139, 4037-4043 (1998)(PMID:9751480)
3. Kato K et al. Production of the alpha subunit of guanine nucleotide-binding protein GO by neuroendocrine tumors. Cancer Res. 47, 5800-5805 (1987)(PMID:2822234)
4. Takigami S et al. Morphological evidence for two types of Mammalian vomeronasal system. Chem Senses. 29, 301-310 (2004)(PMID:15150143)

Immunohistochemistry

1. Takigami S et al. Projection pattern of vomeronasal neurons to the accessory olfactory bulb in goats. Chem Senses. 25, 387-393 (2000)(PMID:10944501)
2. Matsuoka M et al. Immunocytochemical study of G(i)2alpha and G(o)alpha on the epithelium surface of the rat vomeronasal organ. Chem Senses. 26, 161-166 (2001)(PMID:11238246)
3. Kato K et al. Production of the alpha subunit of guanine nucleotide-binding protein GO by neuroendocrine tumors. Cancer Res. 47, 5800-5805 (1987)(PMID:2822234)
4. Takigami S et al. Morphological evidence for two types of Mammalian vomeronasal system. Chem Senses. 29, 301-310 (2004)(PMID:15150143)
5. Prince JE et al. Robo-2 controls the segregation of a portion of basal vomeronasal sensory neuron axons to the posterior region of the accessory olfactory bulb. J Neurosci. 29,14211-14222 (2009)(PMID:19906969)

Product Specifications

• Application: WB, IP, FC, IC
• Reactivity: Mouse, Human
• Clonality: Polyclonal
• Host: Rabbit
• Immunogen: Recombinant Mouse p27 kip1