Anti 6-4 Photoproducts (6-4PPs) mAb (Clone 64M-2)

Cosmo Bio

Catalog No.: CAC-NM-DND-002

Background<

Prolonged exposure to solar UV radiation may result in harmful acute and chronic effects to the skin (including skin cancers), eye, and immune system. These harmful effects appear to be closely related to UV-induced DNA damage. Indeed, UV-induced DNA damage plays significant roles in cell-cycle arrest, activation of DNA repair, cell killing, mutation, and neoplastic transformation. The major types of DNA damage induced by solar UV radiation are cyclobutane pyrimidine dimers (CPDs), (6–4) photoproducts (6-4PPs), and Dewar valence isomers of 6-4PPs (Dewar photoproducts; DewarPPs) formed between adjacent pyrimidine nucleotides on the same DNA strand. Approximately 70-80% of UV-induced DNA damage is CPDs and the remaining is 6-4PPs and Dewar isomers of 6-4PPs. DewarPPs are produced by the photoisomerization of 6-4PPs by UV radiation around 325 nm. In normal human cells these types of DNA lesions are repaired by nucleotide excision repair (NER).

To better study molecular events surrounding UV-induced DNA damage and repair, Mori et al. previously developed and characterized monoclonal antibody (mAb) specific for CPDs and mAb specific for 6-4PPs (1) while Matsunaga et al. developed and characterized mAb specific for DewarPPs (2). Three of these antibodies (CPDs: clone TDM-2; 6-4PPs: clone 64M-2; DewarPPs: clone DEM-1) continue to be cited frequently in the literature, often for use in ELISA.

This High Sensitivity (6-4)photoproducts (6-4PPs) ELISA Kit is the only commercially available ELISA utilizing anti- 6-4PPs clone 64M-2 and has been optimized for high sensitivity detection of 6-4PPs in DNA purified from cultured cells or from skin epidermis. This ELISA detects 6-4PPs from dipyrimidines in all DNA sequence contexts (i.e., TT, TC, CT and CC). Thus, the availability and convenience of this ELISA Kit will contribute to further understanding molecular mechanisms involved in cellular responses to UV radiation and DNA damage with applications across many research fields including cancer research, photobiology, dermatology, ophthalmology, immunology, and cosmetics science.

References

1) Yamamoto, A., et al., DNA Repair, 6, 649-657 (2007).
2) Matsumoto, M., et al., J. Cell Sci., 120, 1104-1112 (2007).
3) Yasuda, G., et al., Mol. Cell. Biol., 27, 6606-6614 (2007).
4) Sugasawa, K., et al., Cell 121, 387-400 (2005).
5) Nishiwaki, Y., et al., J. Invest. Dermatol. 122, 526-532 (2004).
6) Imoto, K., et al., J. Invest. Dermatol. 119, 1177-7782 (2002).
7) Wakasugi, M., et al., J. Biol. Chem., 277, 1637-1640 (2002).
8) Kobayashi, N., et al., Pigment Cell Res. 14, 94-102 (2001).
9) Katsumi, S., et al., J. Invest. Dermatol. 117, 1156-1161 (2001).
10) Otoshi, E., et al., Cancer Res. 60, 1729-1735 (2000).
11) Nakagawa, A., et al., J. Invest. Dermatol. 110, 143-148 (1998).
12) Kobayashi, N., et al., J. Invest. Dermatol. 110, 806-810 (1998).
13) Komatsu, Y., et al., Nucleic Acids Res. 25, 3889-3894 (1997).
14) Nakane, H., et al., Nature 377, 165-168 (1995).
15) Todo, T., et al., Nature 361, 371-374 (1993).
16) Kobayashi, N., et al., J. Invest. Dermatol. 101, 685-689 (1993).
17) Potten, C.S., et al., Int. J. Radiat. Biol. 63, 313-324 (1993).
18) Matsunaga, T., et al., Photochem. Photobiol. 54, 403-410 (1991).
19) Mori, T., et al., Photochem. Photobiol. 54, 225-232 (1991).

More than 200 papers using TDM-2 and 64M-2 antibodies have been published so far.

Product Specifications

• Application: ICC, ELISA, WB, IP, IHC, FC
• Reactivity: All
• Clonality: Monoclonal (Clone No.: 64M-2)
• Host: Mouse

Citations for Anti 6-4 Photoproducts (6-4PPs) mAb (Clone 64M-2) – 106 Found

Han, Chunhua; Srivastava, Amit Kumar; Cui, Tiantian; Wang, Qi-En; Wani, Altaf A. Differential DNA lesion formation and repair in heterochromatin and euchromatin. Carcinogenesis. 2016;37(2):129-38. 

Kemp, Michael G; Sancar, Aziz. ATR Kinase Inhibition Protects Non-cycling Cells from the Lethal Effects of DNA Damage and Transcription Stress. The Journal Of Biological Chemistry. 2016;291(17):9330-42. 

Canturk, Fazile; Karaman, Muhammet; Selby, Christopher P; Kemp, Michael G; Kulaksiz-Erkmen, Gulnihal; Hu, Jinchuan; Li, Wentao; Lindsey-Boltz, Laura A; Sancar, Aziz. Nucleotide excision repair by dual incisions in plants. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2016;113(17):4706-10. 

Higa, Mitsuru; Zhang, Xue; Tanaka, Kiyoji; Saijo, Masafumi. Stabilization of Ultraviolet (UV)-stimulated Scaffold Protein A by Interaction with Ubiquitin-specific Peptidase 7 Is Essential for Transcription-coupled Nucleotide Excision Repair. The Journal Of Biological Chemistry. 2016;291(26):13771-9. 

Choi, Jun-Hyuk; Kim, So-Young; Kim, Sook-Kyung; Kemp, Michael G; Sancar, Aziz. An Integrated Approach for Analysis of the DNA Damage Response in Mammalian Cells: NUCLEOTIDE EXCISION REPAIR, DNA DAMAGE CHECKPOINT, AND APOPTOSIS. The Journal Of Biological Chemistry. 2015;290(48):28812-21. 

Schuch, André P; Lipinski, Victor M; Santos, Mauricio B; Santos, Caroline P; Jardim, Sinara S; Cechin, Sonia Z; Loreto, Elgion L S. Molecular and sensory mechanisms to mitigate sunlight-induced DNA damage in treefrog tadpoles. The Journal Of Experimental Biology. 2015;218(Pt 19):3059-67. 

Hu, Jinchuan; Adar, Sheera; Selby, Christopher P; Lieb, Jason D; Sancar, Aziz. Genome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution. Genes & Development. 2015;29(9):948-60. 

Matsumoto, Syota; Fischer, Eric S; Yasuda, Takeshi; Dohmae, Naoshi; Iwai, Shigenori; Mori, Toshio; Nishi, Ryotaro; Yoshino, Ken-ichi; Sakai, Wataru; Hanaoka, Fumio; Thomä, Nicolas H; Sugasawa, Kaoru. Functional regulation of the DNA damage-recognition factor DDB2 by ubiquitination and interaction with xeroderma pigmentosum group C protein. Nucleic Acids Research. 2015;43(3):1700-13. 

Peacock, Matthew; Brem, Reto; Macpherson, Peter; Karran, Peter. DNA repair inhibition by UVA photoactivated fluoroquinolones and vemurafenib. Nucleic Acids Research. 2014;42(22):13714-22. 

Kemp, Michael G; Gaddameedhi, Shobhan; Choi, Jun-Hyuk; Hu, Jinchuan; Sancar, Aziz. DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair. The Journal Of Biological Chemistry. 2014;289(38):26574-26583. 

Lee, Ming-Hsiang; Wang, Liya; Chang, Zee-Fen. The contribution of mitochondrial thymidylate synthesis in preventing the nuclear genome stress. Nucleic Acids Research. 2014;42(8):4972-84. 

Ming, Mei; Shea, Christopher R; Guo, Xiumei; Li, Xiaoling; Soltani, Keyoumars; Han, Weinong; He, Yu-Ying. Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2010;107(52):22623-8. 

Saijo, Masafumi; Takedachi, Arato; Tanaka, Kiyoji. Nucleotide excision repair by mutant xeroderma pigmentosum group A (XPA) proteins with deficiency in interaction with RPA. The Journal Of Biological Chemistry. 2011;286(7):5476-83. 

Overmeer, René M; Moser, Jill; Volker, Marcel; Kool, Hanneke; Tomkinson, Alan E; van Zeeland, Albert A; Mullenders, Leon H F; Fousteri, Maria. Replication protein A safeguards genome integrity by controlling NER incision events. The Journal Of Cell Biology. 2011;192(3):401-15. 

Kraft, Stephanie; Obst, Ursula; Schwartz, Thomas. Immunological detection of UV induced cyclobutane pyrimidine dimers and (6-4) photoproducts in DNA from reference bacteria and natural aquatic populations. Journal Of Microbiological Methods. 2011;84(3):435-41. 

Kang, Tae-Hong; Reardon, Joyce T; Sancar, Aziz. Regulation of nucleotide excision repair activity by transcriptional and post-transcriptional control of the XPA protein. Nucleic Acids Research. 2011;39(8):3176-87. 

Guervilly, Jean-Hugues; Renaud, Emilie; Takata, Minoru; Rosselli, Filippo. USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation. Human Molecular Genetics. 2011;20(11):2171-81. 

Han, Weinong; Ming, Mei; He, Yu-Ying. Caffeine promotes ultraviolet B-induced apoptosis in human keratinocytes without complete DNA repair. The Journal Of Biological Chemistry. 2011;286(26):22825-32. 

Renaud, Emilie; Miccoli, Laurent; Zacal, Natalie; Biard, Denis S; Craescu, Constantin T; Rainbow, Andrew J; Angulo, Jaime F. Differential contribution of XPC, RAD23A, RAD23B and CENTRIN 2 to the UV-response in human cells. Dna Repair. 2011;10(8):835-47. 

Soares, Daniele G; Machado, Miriana S; Rocca, Céline J; Poindessous, Virginie; Ouaret, Djamila; Sarasin, Alain; Galmarini, Carlos M; Henriques, João A P; Escargueil, Alexandre E; Larsen, Annette K. Trabectedin and its C subunit modified analogue PM01183 attenuate nucleotide excision repair and show activity toward platinum-resistant cells. Molecular Cancer Therapeutics. 2011;10(8):1481-9. 

Gaddameedhi, Shobhan; Selby, Christopher P; Kaufmann, William K; Smart, Robert C; Sancar, Aziz. Control of skin cancer by the circadian rhythm. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2011;108(46):18790-5. 

Jarrett, Stuart G; Novak, Marian; Dabernat, Sandrine; Daniel, Jean-Yves; Mellon, Isabel; Zhang, Qingbei; Harris, Nathan; Ciesielski, Michael J; Fenstermaker, Robert A; Kovacic, Diane; Slominski, Andrzej; Kaetzel, David M. Metastasis suppressor NM23-H1 promotes repair of UV-induced DNA damage and suppresses UV-induced melanomagenesis. Cancer Research. 2012;72(1):133-43. 

Hu, Jinchuan; Choi, Jun-Hyuk; Gaddameedhi, Shobhan; Kemp, Michael G; Reardon, Joyce T; Sancar, Aziz. Nucleotide excision repair in human cells: fate of the excised oligonucleotide carrying DNA damage in vivo. The Journal Of Biological Chemistry. 2013;288(29):20918-20926. 

Choi, Jun-Hyuk; Gaddameedhi, Shobhan; Kim, So-Young; Hu, Jinchuan; Kemp, Michael G; Sancar, Aziz. Highly specific and sensitive method for measuring nucleotide excision repair kinetics of ultraviolet photoproducts in human cells. Nucleic Acids Research. 2014;42(4):e29. 

Kuschal, Christiane; DiGiovanna, John J; Khan, Sikandar G; Gatti, Richard A; Kraemer, Kenneth H. Repair of UV photolesions in xeroderma pigmentosum group C cells induced by translational readthrough of premature termination codons. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2013;110(48):19483-8. 

Duan, Ming-Rui; Smerdon, Michael J. UV damage in DNA promotes nucleosome unwrapping. The Journal Of Biological Chemistry. 2010;285(34):26295-303. 

Overmeer, René M; Gourdin, Audrey M; Giglia-Mari, Ambra; Kool, Hanneke; Houtsmuller, Adriaan B; Siegal, Gregg; Fousteri, Maria I; Mullenders, Leon H F; Vermeulen, Wim. Replication factor C recruits DNA polymerase delta to sites of nucleotide excision repair but is not required for PCNA recruitment. Molecular And Cellular Biology. 2010;30(20):4828-39. 

Li, Wentao; Liu, Wenjie; Kakoki, Ayano; Wang, Rujin; Adebali, Ogun; Jiang, Yuchao; Sancar, Aziz. Nucleotide excision repair capacity increases during differentiation of human embryonic carcinoma cells into neurons and muscle cells. The Journal Of Biological Chemistry. 2019;294(15):5914-5922. 

Fouquerel, Elise; Barnes, Ryan P; Wang, Hong; Opresko, Patricia L. Measuring UV Photoproduct Repair in Isolated Telomeres and Bulk Genomic DNA. Methods In Molecular Biology (Clifton, N.j.). 1999( 31127586):295-306. 

Yang, Guang; Komaki, Yukako; Yoshida, Ikuma; Ibuki, Yuko. Formaldehyde inhibits UV-induced phosphorylation of histone H2AX. Toxicology In Vitro : An International Journal Published In Association With Bibra. 2019;61( 31614172):104687. 

Karaman, Muhammet. The Nucleic Acids' Immunoprecipitation Method for DNA Repair Research. Methods In Molecular Biology (Clifton, N.j.). 2959:37-53. 

Watanabe, Takaaki; Yoshinami, Daiyu; Yamasaki, Hiroyuki; Tanaka, Yukiko; Ohtsuka, Masato; Taniguchi, Toshiyasu. DGCR8 regulates multiple processes of transcription coupled nucleotide excision repair. Scientific Reports. 2026;16(1):7112. 

Kim, Geun Hoe; Kwon, Ha-Jeong; Kim, Youngmin; Kemp, Michael G; Choi, Jun-Hyuk. Development of a competitive immunoassay platform for quantifying the oligonucleotide products of nucleotide excision repair in UV-irradiated cells. Nucleic Acids Research. 2026;54(5) 

Khan, Saman; Nair, Angitha; Carpenter, M Alexandra; Kemp, Michael G. RAD51 and RAD51 paralog inhibition sensitizes nonreplicating quiescent keratinocytes to UV radiation. Photochemistry And Photobiology. 2026; 41674032 

Kim, Mihyun; Jeong, Eunwoo; Park, Jiyoung; D'Souza, Areetha; Tsai, Miaw-Sheue; Yan, Chunli; Ivanov, Ivaylo; Chazin, Walter J; Kim, Hyun Suk; Schärer, Orlando D. The interaction of XPG with TFIIH through p62 and XPD is required for the completion of nucleotide excision repair. Nucleic Acids Research. 2026;54(4) 

Oda, Yuko; Meyer, Mark B; Yeh, Iwei; Lin, Zhiyun; Wong, Christian T; Oh, Dennis; Bikle, Daniel D. Deletion of vitamin D receptor with calcium sensing receptor in keratinocytes promotes epidermal tumorigenesis by limiting dna repair and oxidative stress response genes. The Journal Of Steroid Biochemistry And Molecular Biology. 2026;260:106993. 

Zhou, Shuyan; Zhang, Yi; Li, Zongzhu; Li, Zhuqing; Latham, Patricia S; Meng, Yunxiao; Chen, Wen; Yang, Penghua; Hou, Chunyan; Ma, Junfeng; Zhu, Wenge. And-1 coordinates with polymerase δ to regulate nucleotide excision repair and UVB-induced skin tumorigenesis. Nature Communications. 2025;16(1):9313. 

Dangerfield, Jillian; Mukherjee, Anirban; Reh, Wade; Battenhouse, Anna; Vasquez, Karen M. High-Mobility Group Box Protein 3 (HMGB3) Facilitates DNA Interstrand Crosslink Processing and Double-Strand Break Repair in Human Cells. Genes. 2025;16(9) 

Acedera, Jack Dalit; Cheng, Yu-Che; Li, Yi-Ju; Hsueh, Hao-Yun; Shieh, Sheau-Yann. BTG3-dependent VCP/p97 nuclear translocation is required for efficient repair of UV-induced DNA lesions. Nucleic Acids Research. 2025;53(13) 

Liu, Jiena; Lu, Qing; Fan, Zixuan; Lin, Jiahui; He, Nan; Zhang, Xin; Han, Zhaoya; Zhu, Tingting; Wu, Zhenzhen; Xu, Yingying; Wang, Yuming. IncRNA-ZFAS1, an Emerging Gate-Keeper in DNA Damage-Dependent Transcriptional Regulation. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 2025;12(31):e12385. 

Kose, Cansu; Azgari, Cem; Lindsey-Boltz, Laura A; Adebali, Ogün; Sancar, Aziz. Chromatin context shapes DNA damage formation and nucleotide excision repair dynamics in Caenorhabditis elegans. Nucleic Acids Research. 2025;53(20) 

Suzuki, Takashi; Komaki, Yukako; Amano, Momoka; Ando, Satoko; Shobu, Kosuke; Ibuki, Yuko. Faulty Gap Filling in Nucleotide Excision Repair Leads to Double-Strand Break Formation in Senescent Cells. The Journal Of Investigative Dermatology. 2025;145(1):32-41.e11. 

Zhou, Yilong; Panhale, Amol; Shvedunova, Maria; Balan, Mirela; Gomez-Auli, Alejandro; Holz, Herbert; Seyfferth, Janine; Helmstädter, Martin; Kayser, Séverine; Zhao, Yuling; Erdogdu, Niyazi Umut; Grzadzielewska, Iga; Mittler, Gerhard; Manke, Thomas; Akhtar, Asifa. RNA damage compartmentalization by DHX9 stress granules. Cell. 2024;187(7):1701-1718.e28. 

Blee, Alexandra M; Gallagher, Kaitlyn S; Kim, Hyun-Suk; Kim, Mihyun; Kharat, Suhas S; Troll, Christina R; D'Souza, Areetha; Park, Jiyoung; Neufer, P Drew; Schärer, Orlando D; Chazin, Walter J. XPA tumor variant leads to defects in NER that sensitize cells to cisplatin. Nar Cancer. 2024;6(1):zcae013. 

Prosz, Aurel; Sahgal, Pranshu; Huffman, Brandon M; Sztupinszki, Zsofia; Morris, Clare X; Chen, David; Börcsök, Judit; Diossy, Miklos; Tisza, Viktoria; Spisak, Sandor; Likasitwatanakul, Pornlada; Rusz, Orsolya; Csabai, Istvan; Cecchini, Michael; Baca, Yasmine; Elliott, Andrew; Enzinger, Peter; Singh, Harshabad; Ubellaker, Jessalyn; Lazaro, Jean-Bernard; Cleary, James M; Szallasi, Zoltan; Sethi, Nilay S. Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting. Npj Precision Oncology. 2024;8(1):87. 

Sato, Kazuomi; Sato, Taiki; Hirotani, Riku; Bam, Munetsugu. Effect of combined blue light and 5-ALA on mitochondrial functions and cellular responses in B16F1 melanoma and HaCaT cells. Cytotechnology. 2024;76(6):795-816. 

Carpenter, M Alexandra; Yerrapragada, Sri; Alex, Aleena; Kemp, Michael G. Protocol for immunodot blot detection of UVB photoproducts in extracellular DNA. Star Protocols. 2024;5(1):102838. 

Zhivagui, Maria; Hoda, Areebah; Valenzuela, Noelia; Yeh, Yi-Yu; Dai, Jason; He, Yudou; Nandi, Shuvro P; Otlu, Burcak; Van Houten, Bennett; Alexandrov, Ludmil B. DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer. Nature Communications. 2023;14(1):276. 

Bujarrabal-Dueso, Arturo; Sendtner, Georg; Meyer, David H; Chatzinikolaou, Georgia; Stratigi, Kalliopi; Garinis, George A; Schumacher, Björn. The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities. Nature Structural & Molecular Biology. 2023;30(4):475-488. 

Kusakabe, Masayuki; Sugasawa, Kaoru. Fluorescence-microscopy-based assay assessing regulatory mechanisms of global genome nucleotide excision repair in cultured cells. Star Protocols. 2023;4(3):102378. 

Mielko, Zachery; Zhang, Yuning; Sahay, Harshit; Liu, Yiling; Schaich, Matthew A; Schnable, Brittani; Morrison, Abigail M; Burdinski, Debbie; Adar, Sheera; Pufall, Miles; Van Houten, Bennett; Gordân, Raluca; Afek, Ariel. UV irradiation remodels the specificity landscape of transcription factors. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2023;120(11):e2217422120. 

Schleusener, Johannes; Lohan, Silke B; Busch, Loris; Zamudio Díaz, Daniela F; Opitz, Nevin; Sicher, Claudia; Lichtenthäler, Tom; Danker, Kerstin; Dommerich, Steffen; Filler, Thomas; Meinke, Martina C; Zwicker, Paula. Irradiation of human oral mucosa by 233 nm far UV-C LEDs for the safe inactivation of nosocomial pathogens. Scientific Reports. 2023;13(1):22391. 

Gautam, Amit; Fawcett, Heather; Burdova, Kamila; Brazina, Jan; Caldecott, Keith W. APE1-dependent base excision repair of DNA photodimers in human cells. Molecular Cell. 2023;83(20):3669-3678.e7. 

Kim, Mihyun; Kim, Hyun-Suk; D'Souza, Areetha; Gallagher, Kaitlyn; Jeong, Eunwoo; Topolska-Wós, Agnieszka; Ogorodnik Le Meur, Kateryna; Tsai, Chi-Lin; Tsai, Miaw-Sheue; Kee, Minyong; Tainer, John A; Yeo, Jung-Eun; Chazin, Walter J; Schärer, Orlando D. Two interaction surfaces between XPA and RPA organize the preincision complex in nucleotide excision repair. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2022;119(34):e2207408119. 

Vougioukalaki, Maria; Demmers, Joris; Vermeij, Wilbert P; Baar, Marjolein; Bruens, Serena; Magaraki, Aristea; Kuijk, Ewart; Jager, Myrthe; Merzouk, Sarra; Brandt, Renata M C; Kouwenberg, Janneke; van Boxtel, Ruben; Cuppen, Edwin; Pothof, Joris; Hoeijmakers, Jan H J. Different responses to DNA damage determine ageing differences between organs. Aging Cell. 2022;21(4):e13562. 

Kusakabe, Masayuki; Kakumu, Erina; Kurihara, Fumika; Tsuchida, Kazuki; Maeda, Takumi; Tada, Haruto; Kusao, Kanako; Kato, Akari; Yasuda, Takeshi; Matsuda, Tomonari; Nakao, Mitsuyoshi; Yokoi, Masayuki; Sakai, Wataru; Sugasawa, Kaoru. Histone deacetylation regulates nucleotide excision repair through an interaction with the XPC protein. Iscience. 2022;25(4):104040. 

Schavinski, Cassiano Ricardo; Santos, Maurício Beux Dos; Londero, James Eduardo Lago; Rocha, Marcelo Carvalho da; Amaral, Aline Monique Blank do; Ruiz, Nathalia Quintero; Leandro, Giovana da Silva; Loro, Vania Lucia; Schuch, André Passaglia. Effects of isolated and combined exposures of Boana curupi (Anura: Hylidae) tadpoles to environmental doses of trichlorfon and ultraviolet radiation. Mutation Research. Genetic Toxicology And Environmental Mutagenesis. 2022;883-884:503549. 

Senju, Chikako; Nakazawa, Yuka; Shimada, Mayuko; Iwata, Dai; Matsuse, Michiko; Tanaka, Katsumi; Miyazaki, Yasushi; Moriwaki, Shinichi; Mitsutake, Norisato; Ogi, Tomoo. Aicardi-Goutières syndrome with SAMHD1 deficiency can be diagnosed by unscheduled DNA synthesis test. Frontiers In Pediatrics. 10:1048002. 

Lee, Shin-Ai; Lee, Daye; Kang, Minhwa; Kim, Sora; Kwon, Su-Jung; Lee, Han-Sae; Seo, Hye-Ran; Kaushal, Prashant; Lee, Nam Soo; Kim, Hongtae; Lee, Cheolju; Kwon, Jongbum. BAP1 promotes the repair of UV-induced DNA damage via PARP1-mediated recruitment to damage sites and control of activity and stability. Cell Death And Differentiation. 2022;29(12):2381-2398. 

Bui, Thi Kim Ngan; Mawatari, Kazuaki; Emoto, Takahiro; Fukushima, Shiho; Shimohata, Takaaki; Uebanso, Takashi; Akutagawa, Masatake; Kinouchi, Yohsuke; Takahashi, Akira. UV-LED irradiation reduces the infectivity of herpes simplex virus type 1 by targeting different viral components depending on the peak wavelength. Journal Of Photochemistry And Photobiology. B, Biology. 2022;228:112410. 

van Toorn, Marvin; Turkyilmaz, Yasemin; Han, Sueji; Zhou, Di; Kim, Hyun-Suk; Salas-Armenteros, Irene; Kim, Mihyun; Akita, Masaki; Wienholz, Franziska; Raams, Anja; Ryu, Eunjin; Kang, Sukhyun; Theil, Arjan F; Bezstarosti, Karel; Tresini, Maria; Giglia-Mari, Giuseppina; Demmers, Jeroen A; Schärer, Orlando D; Choi, Jun-Hyuk; Vermeulen, Wim; Marteijn, Jurgen A. Active DNA damage eviction by HLTF stimulates nucleotide excision repair. Molecular Cell. 2022;82(7):1343-1358.e8. 

Zwicker, Paula; Schleusener, Johannes; Lohan, Silke B; Busch, Loris; Sicher, Claudia; Einfeldt, Sven; Kneissl, Michael; Kühl, Anja A; Keck, Cornelia M; Witzel, Christian; Kramer, Axel; Meinke, Martina C. Application of 233 nm far-UVC LEDs for eradication of MRSA and MSSA and risk assessment on skin models. Scientific Reports. 2022;12(1):2587. 

Golan Berman, Hadar; Chauhan, Pooja; Shalev, Shira; Hassanain, Hiba; Parnas, Avital; Adar, Sheera. Genomic Characterization of Cisplatin Response Uncovers Priming of Cisplatin-Induced Genes in a Resistant Cell Line. International Journal Of Molecular Sciences. 2021;22(11) 

Wong, Christian T; Oh, Dennis H. Vitamin D Receptor Promotes Global Nucleotide Excision Repair by Facilitating XPC Dissociation from Damaged DNA. The Journal Of Investigative Dermatology. 2021;141(7):1656-1663. 

Kobaisi, Farah; Sulpice, Eric; Barette, Caroline; Fayyad, Nour; Fauvarque, Marie-Odile; Badran, Bassam; Fayyad-Kazan, Mohammad; Fayyad-Kazan, Hussein; Gidrol, Xavier; Rachidi, Walid. Isoconazole and Clemizole Hydrochloride Partially Reverse the Xeroderma Pigmentosum C Phenotype. International Journal Of Molecular Sciences. 2021;22(15) 

Glaab, Johannes; Lobo-Ploch, Neysha; Cho, Hyun Kyong; Filler, Thomas; Gundlach, Heiko; Guttmann, Martin; Hagedorn, Sylvia; Lohan, Silke B; Mehnke, Frank; Schleusener, Johannes; Sicher, Claudia; Sulmoni, Luca; Wernicke, Tim; Wittenbecher, Lucas; Woggon, Ulrike; Zwicker, Paula; Kramer, Axel; Meinke, Martina C; Kneissl, Michael; Weyers, Markus; Winterwerber, Ulrike; Einfeldt, Sven. Author Correction: Skin tolerant inactivation of multiresistant pathogens using far-UVC LEDs. Scientific Reports. 2022;12(1):7702. 

Sakai, Wataru; Yuasa-Sunagawa, Mayumi; Kusakabe, Masayuki; Kishimoto, Aiko; Matsui, Takeshi; Kaneko, Yuki; Akagi, Jun-Ichi; Huyghe, Nicolas; Ikura, Masae; Ikura, Tsuyoshi; Hanaoka, Fumio; Yokoi, Masayuki; Sugasawa, Kaoru. Functional impacts of the ubiquitin-proteasome system on DNA damage recognition in global genome nucleotide excision repair. Scientific Reports. 2020;10(1):19704. 

Mandemaker, Imke K; Zhou, Di; Bruens, Serena T; Dekkers, Dick H; Verschure, Pernette J; Edupuganti, Raghu R; Meshorer, Eran; Demmers, Jeroen A A; Marteijn, Jurgen A. Histone H1 eviction by the histone chaperone SET reduces cell survival following DNA damage. Journal Of Cell Science. 2020;133(9) 

Fouquerel, Elise; Barnes, Ryan P; Wang, Hong; Opresko, Patricia L. Measuring UV Photoproduct Repair in Isolated Telomeres and Bulk Genomic DNA. Methods In Molecular Biology (Clifton, N.j.). 1999:295-306. 

Hu, Jinchuan; Li, Wentao; Adebali, Ogun; Yang, Yanyan; Oztas, Onur; Selby, Christopher P; Sancar, Aziz. Genome-wide mapping of nucleotide excision repair with XR-seq. Nature Protocols. 2019;14(1):248-282. 

Steurer, Barbara; Turkyilmaz, Yasemin; van Toorn, Marvin; van Leeuwen, Wessel; Escudero-Ferruz, Paula; Marteijn, Jurgen A. Fluorescently-labelled CPD and 6-4PP photolyases: new tools for live-cell DNA damage quantification and laser-assisted repair. Nucleic Acids Research. 2019;47(7):3536-3549. 

Chaiprasongsuk, Anyamanee; Janjetovic, Zorica; Kim, Tae-Kang; Jarrett, Stuart G; D'Orazio, John A; Holick, Michael F; Tang, Edith K Y; Tuckey, Robert C; Panich, Uraiwan; Li, Wei; Slominski, Andrzej T. Protective effects of novel derivatives of vitamin D(3) and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and p53 defense mechanisms. Redox Biology. 2019;24:101206. 

Graindorge, Stéfanie; Cognat, Valérie; Johann To Berens, Philippe; Mutterer, Jérôme; Molinier, Jean. Photodamage repair pathways contribute to the accurate maintenance of the DNA methylome landscape upon UV exposure. Plos Genetics. 2019;15(11):e1008476. 

Aleksandrov, Radoslav; Dotchev, Anton; Poser, Ina; Krastev, Dragomir; Georgiev, Georgi; Panova, Greta; Babukov, Yordan; Danovski, Georgi; Dyankova, Teodora; Hubatsch, Lars; Ivanova, Aneliya; Atemin, Aleksandar; Nedelcheva-Veleva, Marina N; Hasse, Susanne; Sarov, Mihail; Buchholz, Frank; Hyman, Anthony A; Grill, Stephan W; Stoynov, Stoyno S. Protein Dynamics in Complex DNA Lesions. Molecular Cell. 2018;69(6):1046-1061.e5. 

Rieckher, Matthias; Bujarrabal, Arturo; Doll, Markus A; Soltanmohammadi, Najmeh; Schumacher, Björn. A simple answer to complex questions: Caenorhabditis elegans as an experimental model for examining the DNA damage response and disease genes. Journal Of Cellular Physiology. 2018;233(4):2781-2790. 

Alekseev, Sergey; Nagy, Zita; Sandoz, Jérémy; Weiss, Amélie; Egly, Jean-Marc; Le May, Nicolas; Coin, Frederic. Transcription without XPB Establishes a Unified Helicase-Independent Mechanism of Promoter Opening in Eukaryotic Gene Expression. Molecular Cell. 2017;65(3):504-514.e4. 

Murata, Yasumasa; Osakabe, Masahiro. Photo-enzymatic repair of UVB-induced DNA damage in the two-spotted spider mite Tetranychus urticae. Experimental & Applied Acarology. 2017;71(1):15-34. 

Nakamura, Tomohumi; Murakami, Kouichi; Tada, Haruto; Uehara, Yoshihiko; Nogami, Jumpei; Maehara, Kazumitsu; Ohkawa, Yasuyuki; Saitoh, Hisato; Nishitani, Hideo; Ono, Tetsuya; Nishi, Ryotaro; Yokoi, Masayuki; Sakai, Wataru; Sugasawa, Kaoru. Thymine DNA glycosylase modulates DNA damage response and gene expression by base excision repair-dependent and independent mechanisms. Genes To Cells : Devoted To Molecular & Cellular Mechanisms. 2017;22(4):392-405. 

Mazouzi, Abdelghani; Battistini, Federica; Moser, Sarah C; Ferreira da Silva, Joana; Wiedner, Marc; Owusu, Michel; Lardeau, Charles-Hugues; Ringler, Anna; Weil, Beatrix; Neesen, Jürgen; Orozco, Modesto; Kubicek, Stefan; Loizou, Joanna I. Repair of UV-Induced DNA Damage Independent of Nucleotide Excision Repair Is Masked by MUTYH. Molecular Cell. 2017;68(4):797-807.e7. 

Muñoz, Manuel J; Nieto Moreno, Nicolás; Giono, Luciana E; Cambindo Botto, Adrián E; Dujardin, Gwendal; Bastianello, Giulia; Lavore, Stefania; Torres-Méndez, Antonio; Menck, Carlos F M; Blencowe, Benjamin J; Irimia, Manuel; Foiani, Marco; Kornblihtt, Alberto R. Major Roles for Pyrimidine Dimers, Nucleotide Excision Repair, and ATR in the Alternative Splicing Response to UV Irradiation. Cell Reports. 2017;18(12):2868-2879. 

Mallet, Justin D; Dorr, Marie M; Drigeard Desgarnier, Marie-Catherine; Bastien, Nathalie; Gendron, Sébastien P; Rochette, Patrick J. Faster DNA Repair of Ultraviolet-Induced Cyclobutane Pyrimidine Dimers and Lower Sensitivity to Apoptosis in Human Corneal Epithelial Cells than in Epidermal Keratinocytes. Plos One. 11(9):e0162212. 

Qiang, Lei; Zhao, Baozhong; Shah, Palak; Sample, Ashley; Yang, Seungwon; He, Yu-Ying. Autophagy positively regulates DNA damage recognition by nucleotide excision repair. Autophagy. 12(2):357-68. 

Holcomb, Nathaniel; Goswami, Mamta; Han, Sung Gu; Clark, Samuel; Orren, David K; Gairola, C Gary; Mellon, Isabel. Exposure of Human Lung Cells to Tobacco Smoke Condensate Inhibits the Nucleotide Excision Repair Pathway. Plos One. 11(7):e0158858. 

Tyagi, Nikhil; Srivastava, Sanjeev K; Arora, Sumit; Omar, Yousef; Ijaz, Zohaib Mohammad; Al-Ghadhban, Ahmed; Deshmukh, Sachin K; Carter, James E; Singh, Ajay P; Singh, Seema. Comparative analysis of the relative potential of silver, Zinc-oxide and titanium-dioxide nanoparticles against UVB-induced DNA damage for the prevention of skin carcinogenesis. Cancer Letters. 2016;383(1):53-61. 

Weems, Juston C; Slaughter, Brian D; Unruh, Jay R; Hall, Shawn M; McLaird, Merry B; Gilmore, Joshua M; Washburn, Michael P; Florens, Laurence; Yasukawa, Takashi; Aso, Teijiro; Conaway, Joan W; Conaway, Ronald C. Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses. The Journal Of Biological Chemistry. 2015;290(24):15030-41. 

Okuda, Masahiko; Kinoshita, Minoru; Kakumu, Erina; Sugasawa, Kaoru; Nishimura, Yoshifumi. Structural Insight into the Mechanism of TFIIH Recognition by the Acidic String of the Nucleotide Excision Repair Factor XPC. Structure (London, England : 1993). 2015;23(10):1827-1837. 

Matsumoto, Syota; Fischer, Eric S; Yasuda, Takeshi; Dohmae, Naoshi; Iwai, Shigenori; Mori, Toshio; Nishi, Ryotaro; Yoshino, Ken-ichi; Sakai, Wataru; Hanaoka, Fumio; Thomä, Nicolas H; Sugasawa, Kaoru. Functional regulation of the DNA damage-recognition factor DDB2 by ubiquitination and interaction with xeroderma pigmentosum group C protein. Nucleic Acids Research. 2015;43(3):1700-13. 

Parikh, Dhvani; Fouquerel, Elise; Murphy, Connor T; Wang, Hong; Opresko, Patricia L. Telomeres are partly shielded from ultraviolet-induced damage and proficient for nucleotide excision repair of photoproducts. Nature Communications. 2015;6:8214. 

Akita, Masaki; Tak, Yon-Soo; Shimura, Tsutomu; Matsumoto, Syota; Okuda-Shimizu, Yuki; Shimizu, Yuichiro; Nishi, Ryotaro; Saitoh, Hisato; Iwai, Shigenori; Mori, Toshio; Ikura, Tsuyoshi; Sakai, Wataru; Hanaoka, Fumio; Sugasawa, Kaoru. SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair. Scientific Reports. 2015;5:10984. 

van Cuijk, Loes; van Belle, Gijsbert J; Turkyilmaz, Yasemin; Poulsen, Sara L; Janssens, Roel C; Theil, Arjan F; Sabatella, Mariangela; Lans, Hannes; Mailand, Niels; Houtsmuller, Adriaan B; Vermeulen, Wim; Marteijn, Jurgen A. SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair. Nature Communications. 2015;6:7499. 

Mueller, Michael M; Castells-Roca, Laia; Babu, Vipin; Ermolaeva, Maria A; Müller, Roman-Ulrich; Frommolt, Peter; Williams, Ashley B; Greiss, Sebastian; Schneider, Jennifer I; Benzing, Thomas; Schermer, Bernhard; Schumacher, Björn. DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage. Nature Cell Biology. 2014;16(12):1168-1179. 

Puumalainen, Marjo-Riitta; Lessel, Davor; Rüthemann, Peter; Kaczmarek, Nina; Bachmann, Karin; Ramadan, Kristijan; Naegeli, Hanspeter. Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity. Nature Communications. 2014;5:3695. 

Tsuge, Maasa; Kaneoka, Hidenori; Masuda, Yusuke; Ito, Hiroki; Miyake, Katsuhide; Iijima, Shinji. Implication of SUMO E3 ligases in nucleotide excision repair. Cytotechnology. 2015;67(4):681-7. 

Verbruggen, Paul; Heinemann, Tim; Manders, Erik; von Bornstaedt, Gesa; van Driel, Roel; Höfer, Thomas. Robustness of DNA repair through collective rate control. Plos Computational Biology. 2014;10(1):e1003438. 

Biswas, Anup Kumar; Mitchell, David L; Johnson, David G. E2F1 responds to ultraviolet radiation by directly stimulating DNA repair and suppressing carcinogenesis. Cancer Research. 2014;74(12):3369-77. 

Gourdin, Audrey M; van Cuijk, Loes; Tresini, Maria; Luijsterburg, Martijn S; Nigg, Alex L; Giglia-Mari, Guiseppina; Houtsmuller, Adriaan B; Vermeulen, Wim; Marteijn, Jurgen A. Differential binding kinetics of replication protein A during replication and the pre- and post-incision steps of nucleotide excision repair. Dna Repair. 2014;24:46-56. 

Fischer, Jan M F; Popp, Oliver; Gebhard, Daniel; Veith, Sebastian; Fischbach, Arthur; Beneke, Sascha; Leitenstorfer, Alfred; Bergemann, Jörg; Scheffner, Martin; Ferrando-May, Elisa; Mangerich, Aswin; Bürkle, Alexander. Poly(ADP-ribose)-mediated interplay of XPA and PARP1 leads to reciprocal regulation of protein function. The Febs Journal. 2014;281(16):3625-41. 

Biswas, Anup Kumar; Mitchell, David L; Johnson, David G. E2F1 responds to ultraviolet radiation by directly stimulating DNA repair and suppressing carcinogenesis. Cancer Research. 2014;74(12):3369-77. 

Buonanno, Manuela; Randers-Pehrson, Gerhard; Bigelow, Alan W; Trivedi, Sheetal; Lowy, Franklin D; Spotnitz, Henry M; Hammer, Scott M; Brenner, David J. 207-nm UV light - a promising tool for safe low-cost reduction of surgical site infections. I: in vitro studies. Plos One. 8(10):e76968. 

Yano, Azuha; Chen, Shi-Ping; Kita, Kazuko; Jiang, Xia; Ren, Qian; Sato, Tetsuo; Suzuki, Nobuo. The involvement of annexin II in resistance to UVB-induced cell death and in the increased nucleotide excision repair capacity of UV-damaged DNA in human cells. Bioscience, Biotechnology, And Biochemistry. 77(2):307-11. 

Su, Yan; Orelli, Barbara; Madireddy, Advaitha; Niedernhofer, Laura J; Schärer, Orlando D. Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair. The Journal Of Biological Chemistry. 2012;287(26):21846-55. 

Schuch, André Passaglia; Yagura, Teiti; Makita, Kazuo; Yamamoto, Hiromasa; Schuch, Nelson Jorge; Agnez-Lima, Lucymara Fassarella; MacMahon, Ricardo Monreal; Menck, Carlos Frederico Martins. DNA damage profiles induced by sunlight at different latitudes. Environmental And Molecular Mutagenesis. 2012;53(3):198-206. 

Fei, Jia; Chen, Junjie. KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR). The Journal Of Biological Chemistry. 2012;287(42):35118-35126. 

Fang, Weiguo; St Leger, Raymond J. Enhanced UV resistance and improved killing of malaria mosquitoes by photolyase transgenic entomopathogenic fungi. Plos One. 7(8):e43069. 

Burgess, Hannah M; Richardson, William A; Anderson, Ross C; Salaun, Christine; Graham, Sheila V; Gray, Nicola K. Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export of metazoan PABPs. Journal Of Cell Science. 2011;124(Pt 19):3344-55. 

Fan, Wei; Luo, Jianyuan. SIRT1 regulates UV-induced DNA repair through deacetylating XPA. Molecular Cell. 2010;39(2):247-58.