Cosmo Bio USA provides an expansive portfolio of bone biology research tools that support investigations into the fundamental processes of skeletal development, remodeling, and disease. The collection includes validated antibodies, ELISA kits, recombinant proteins, and functional assays that target key regulators of osteoblast differentiation and matrix deposition, including RUNX2, Osterix, alkaline phosphatase, osteocalcin, and osteopontin. These products allow researchers to follow the progression from early transcriptional events to late-stage mineralization, offering a reliable means of studying how new bone is formed under physiological and pathological conditions. To complement this focus on formation, Cosmo Bio USA also supplies critical tools for examining osteoclast biology and bone resorption. Assays and reagents for RANKL, Cathepsin K, and TRAP are accompanied by the widely used Bone Resorption Assay Kit, a gold-standard platform for measuring osteoclast activity and evaluating therapeutic compounds designed to mitigate bone loss.
In addition to markers of formation and resorption, the portfolio addresses the signaling pathways and structural proteins that shape bone biology at the systems level. Researchers can explore molecular cascades involving BMPs, Wnt proteins, β-catenin, and inhibitors such as DKK1, all of which are critical to the regulation of osteogenesis, osteoclastogenesis, and skeletal maintenance. Complementary products for collagens, osteopontin, and other extracellular matrix proteins further extend the ability to study bone strength, integrity, and remodeling. Taken together, these resources provide not only breadth across the molecular and cellular drivers of skeletal biology, but also depth in the experimental systems used to measure them. By combining sensitive quantification kits, rigorously validated antibodies, and pathway-specific recombinant proteins, Cosmo Bio USA empowers researchers to accelerate discovery in areas ranging from osteoporosis and arthritis to bone regeneration, fracture repair, and metabolic bone disorders.