Anti Histone Acetyltransferase GCN5 pAb (Rabbit, Antiserum)

Cosmo Bio LTD

Catalog No: BAM-62-003-EX

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Application: WB 
Clonality: Polyclonal 
Host: Rabbit 
Purification: Serum 
Reactivity: S. cerevisiae 
Function: AGA (Spt-Ada-Gen5 histone acetyltransferase complex) is a histone acetylase complex which has Gcn5p as a catalyst subunit and has functions overlapping with the fundamental transcription factor TFIID which has Taf1p as a catalyst subunit. However, SAGA and TFIID have different allotments and each accomplishes the important role in the transcription for Housekeeping gene group and Stress Responding gene group. Also, SAGA is a gigantic protein complex which is composed of Ada protein group (5 kinds), TBP related protein group (4 kinds), TAF protein group (5 kinds that also pertain to TFIID), and other protein groups (>6 kinds). It has the molecular functions such as chemical modification of histone, recruitment by direct interaction of transcription regulating factor on DNA, and control of transcription starting reaction by TBP. Gcn5p that shows histoneacetylase activity is one of the proteins belonging to the above-mentioned Ada protein group and it is composed of 439 amino acid recidues with molecular mass of 51 kDa in the case of budding yeast.