Anti Phospho-SMAD2 (S250) mAb (Clone 4D12)

CUSABIO

SKU: CSB-RA618017A250phHU-50

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Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Product Specifications

• Application: WB, ELISA
• Reactivity: Human
• Clonality: Monoclonal (Clone No.: 4D12)