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Application: ELISA, IHC, WBClonality: Monoclonal
Host: Mouse
Purification: Ig-PG
Reactivity: Rat, Human
UniPlot SummaryFunction// Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved inprotection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.Subunit structure// Homodimer.Subcellular location// Cytoplasm.Tissue specificity// Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium.Sequence similarities// Belongs to the aldo/keto reductase 2 family.Reference1. "cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily,AKR7A3." Knight L.P.et al. Carcinogenesis 20:1215-1223(1999) [PubMed: 10383892] [Abstract]. Cited for: NUCLEOTIDE SEQUENCE[MRNA], CHARACTERIZATION, VARIANTS MET-138; ASP-215 AND ALA-323. Tissue: Liver.2. "Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells." Praml C.etal. Oncogene 22:4765-4773(2003) [PubMed: 12879023] [Abstract]. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY,VARIANTS ASP-215 AND ALA-323.3. "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G. et al. Nature 441:315-321(2006) [PubMed:16710414] [Abstract]. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
Documents & Links for Anti Aldo-Keto Reductase Family 7 Member A3 (AKR7A3) central region mAb (Clone 2B8) | |
Datasheet | Anti Aldo-Keto Reductase Family 7 Member A3 (AKR7A3) central region mAb (Clone 2B8) |
Documents & Links for Anti Aldo-Keto Reductase Family 7 Member A3 (AKR7A3) central region mAb (Clone 2B8) | |
Datasheet | Anti Aldo-Keto Reductase Family 7 Member A3 (AKR7A3) central region mAb (Clone 2B8) |