Human Bone Marrow-Derived Mesenchymal Stem Cells

Cellular Engineering Technologies

Catalog No.: CET-CR1005-500

Human Bone Marrow-Derived Mesenchymal Stem Cells (BMSCs)

Human Bone Marrow-Derived Mesenchymal Stem Cells (BMSCs) are isolated from red marrow collected from a single adult human donor. These cells have undergone three passages to ensure consistency and reliable performance in research applications.

BMSCs exhibit remarkable versatility and are widely used in tissue differentiation applications. BMSCs are critical for maintaining musculoskeletal tissue homeostasis and supporting the growth and differentiation of primitive hematopoietic cells. These cells can differentiate into multiple lineages, including adipogenic, chondrogenic, osteogenic, and neural cell types. Their multipotency makes them invaluable in regenerative medicine, tissue engineering, and disease modeling. Additionally, numerous preclinical and clinical studies use BMSCs, particularly for musculoskeletal regeneration, bone and cartilage repair, and immune modulation.

Due to their ability to regenerate tissue and promote healing, BMSCs offer significant promise in both experimental and therapeutic contexts. Common uses of these cells include: stem cell-based therapies, tissue engineering, and for developing new treatment strategies for degenerative diseases.

Product Specifications:

• Source: Human red bone marrow from a single adult donor
• Multipotency: Capable of differentiating into adipogenic, chondrogenic, osteogenic, and neural lineages
• Applications: Tissue engineering, regenerative medicine, immunotherapy, musculoskeletal research, and disease modeling
• Quality Assurance: Screened for viability, sterility, and mycoplasma contamination

Please contact us for additional donor information.

Recommended Products for Bone Marrow-Derived Mesenchymal Stem Cells:

• Human MSC Expansion Media (CET-MR1016)
• Human Chondrogenic Differentiation Media (CET-MR1008)
• Human Osteogenic Differentiation Media (CET-MR1009)

Shipping & Storage:

• Vial contains approximately 500,000 cells
• Shipped with dry ice or liquid nitrogen to maintain stability and viability during transport
• Storage recommendation: Store in the vapor phase of liquid nitrogen for long-term viability

Citations for Human Bone Marrow-Derived Mesenchymal Stem Cells – 15 Found

Lee, Eun-Shil; Yu, Song-Hee; Jang, Yu-Jin; Hwang, Dong-Youn; Jeon, Chang-Jin. Transplantation of bone marrow-derived mesenchymal stem cells into the developing mouse eye. Acta Histochemica Et Cytochemica. 2011;44(5):213-21. 

Tatsumi, Kohei; Ohashi, Kazuo; Matsubara, Yoshinori; Kohori, Ayako; Ohno, Takahiro; Kakidachi, Hiroshi; Horii, Akihiro; Kanegae, Kazuko; Utoh, Rie; Iwata, Takanori; Okano, Teruo. Tissue factor triggers procoagulation in transplanted mesenchymal stem cells leading to thromboembolism. Biochemical And Biophysical Research Communications. 2013;431(2):203-9. 

Xie, Jingwei; Ma, Bing; Michael, Praveesuda Lorwattanapongsa; Shuler, Franklin D. Fabrication of nanofiber scaffolds with gradations in fiber organization and their potential applications. Macromolecular Bioscience. 2012;12(10):1336-41. 

Lee, Mon-Juan; Chen, Yuhsin; Huang, Yuan-Pin; Hsu, Yi-Chiang; Chiang, Lan-Hsin; Chen, Tzu-Yu; Wang, Gwo-Jaw. Exogenous polyamines promote osteogenic differentiation by reciprocally regulating osteogenic and adipogenic gene expression. Journal Of Cellular Biochemistry. 2013;114(12):2718-28. 

Lai, Guo-Jyun; Shalumon, K T; Chen, Shih-Hsien; Chen, Jyh-Ping. Composite chitosan/silk fibroin nanofibers for modulation of osteogenic differentiation and proliferation of human mesenchymal stem cells. Carbohydrate Polymers. 2014;111:288-97. 

Feng, Yuping; Wang, Jiao; Ling, Shixin; Li, Zhuo; Li, Mingsheng; Li, Qiongyi; Ma, Zongren; Yu, Sijiu. Differentiation of mesenchymal stem cells into neuronal cells on fetal bovine acellular dermal matrix as a tissue engineered nerve scaffold. Neural Regeneration Research. 2014;9(22):1968-78. 

Shalumon, K T; Lai, Guo-Jyun; Chen, Chih-Hao; Chen, Jyh-Ping. Modulation of Bone-Specific Tissue Regeneration by Incorporating Bone Morphogenetic Protein and Controlling the Shell Thickness of Silk Fibroin/Chitosan/Nanohydroxyapatite Core-Shell Nanofibrous Membranes. Acs Applied Materials & Interfaces. 2015;7(38):21170-81. 

Lai, Guo-Jyun; Shalumon, K T; Chen, Jyh-Ping. Response of human mesenchymal stem cells to intrafibrillar nanohydroxyapatite content and extrafibrillar nanohydroxyapatite in biomimetic chitosan/silk fibroin/nanohydroxyapatite nanofibrous membrane scaffolds. International Journal Of Nanomedicine. 10:567-84. 

Tenkumo, Taichi; Vanegas Sáenz, Juan Ramón; Takada, Yukyo; Takahashi, Masatoshi; Rotan, Olga; Sokolova, Viktoriya; Epple, Matthias; Sasaki, Keiichi. Gene transfection of human mesenchymal stem cells with a nano-hydroxyapatite-collagen scaffold containing DNA-functionalized calcium phosphate nanoparticles. Genes To Cells : Devoted To Molecular & Cellular Mechanisms. 2016;21(7):682-95. 

Vanegas Sáenz, Juan Ramón; Tenkumo, Taichi; Kamano, Yuya; Egusa, Hiroshi; Sasaki, Keiichi. Amiloride-enhanced gene transfection of octa-arginine functionalized calcium phosphate nanoparticles. Plos One. 12(11):e0188347. 

Comşa, Şerban; Ceaușu, Raluca Amalia; Popescu, Roxana; Cîmpean, Anca Maria; Raica, Marius. The Human Mesenchymal Stem Cells and the Chick Embryo Chorioallantoic Membrane: The Key and the Lock in Revealing Vasculogenesis. In Vivo (Athens, Greece). 2017;31(6):1139-1144. 

Takahara, Shunsuke; Niikura, Takahiro; Lee, Sang Yang; Iwakura, Takashi; Okumachi, Etsuko; Kuroda, Ryosuke; Kurosaka, Masahiro. Human pseudoarthrosis tissue contains cells with osteogenic potential. Injury. 2016;47(6):1184-90. 

ComŞa, Şerban; CeauȘu, Amalia-Raluca; Popescu, Roxana; SÂrb, Simona; CÎmpean, Anca-Maria; Raica, Marius. The MSC-MCF-7 Duet Playing Tumor Vasculogenesis and Angiogenesis onto the Chick Embryo Chorioallantoic Membrane. In Vivo (Athens, Greece). 2020;34(6):3315-3325. 

Calvert, Nicholas D; Proulx, Scott; Rodriguez-Navarro, Alejandro; Ahmed, Tamer; Lehoux, Eric A; Hincke, Maxwell T; Catelas, Isabelle. Development of hydrogel-based composite scaffolds containing eggshell particles for bone regeneration applications. Journal Of Biomedical Materials Research. Part B, Applied Biomaterials. 2024;112(1):e35296. 

Yudintceva, Natalia; Mikhailova, Natalia; Fedorov, Viacheslav; Samochernych, Konstantin; Vinogradova, Tatiana; Muraviov, Alexandr; Shevtsov, Maxim. Mesenchymal Stem Cells and MSCs-Derived Extracellular Vesicles in Infectious Diseases: From Basic Research to Clinical Practice. Bioengineering (Basel, Switzerland). 2022;9(11)