Collagen Glycation Assay Kit, Glyceraldehyde

Cosmo Bio

SKU: PMC-AK71

For rapid detection of fluorescent AGEs and inhibition assay for glycation of collagen by glyceraldehyde. The non-enzymatic reaction of reducing carbohydrates with lysine or arginine side chains and N-terminal amino groups of macromolecules (proteins, phospholipids and nucleic acids) is called the Maillard reaction or glycation. Theproducts of this process, termed advanced glycation end products (AGEs), adversely affect the functional properties of proteins. Many AGEs have fluorescent and convalent cross-linking properties. Accumulation of AGEs has been thought to play an important role in the pathogenesis of diabetic patients as well as the aging process.

Recent studies have suggested that AGEs can arise not only from sugars but also from carbonyl compounds derived from the autoxidation of sugars and other metabolic pathways. Among different AGEs, there is evidence that glyceraldehyde -derived AGEs are associated with such cytotoxcity.

Collagen Anti-glycation Assay Kit, Glyceraldehyde provides rapid detection of fluorescent AGEs and inhibition assay forglycation of collagen by glyceraldehyde. This kit provides sufficient reagents to perform up to 192 assays.

Principle: Collagen Anti-glycation Assay Kit, Glyceraldehyde is a complete assay system designed to measure the fluorescent AGEs usingthe fluorescence microplate reader equipped with a 370nm excitation filter and 440nm emission filter.