Anti SETDB1 pAb (ATL-HPA018142)

Atlas Antibodies

Catalog No.: ATL-HPA018142-25

Protein Description: SET domain, bifurcated 1
Gene Name: SETDB1
Alternative Gene Name: ESET, KG1T, KIAA0067, KMT1E, TDRD21
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000015697: 97%, ENSRNOG00000021143: 97%
Entrez Gene ID: 9869
Uniprot ID: Q15047
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Product Specifications

• Application: ICC, IHC
• Reactivity: Human
• Clonality: Polyclonal
• Host: Rabbit
• Immunogen: KLRFLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEGTWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRPNMGAVRSKGPVVQYTQD
• Gene Sequence: KLRFLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEGTWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRPNMGAVRSKGPVVQYTQD
• Gene ID - Mouse: ENSMUSG00000015697
• Gene ID - Rat: ENSRNOG00000021143
• Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.

Citations for Anti SETDB1 pAb (ATL-HPA018142) – 5 Found

Sun, Qiao-Yang; Ding, Ling-Wen; Xiao, Jin-Fen; Chien, Wenwen; Lim, Su-Lin; Hattori, Norimichi; Goodglick, Lee; Chia, David; Mah, Vei; Alavi, Mohammad; Kim, Sara R; Doan, Ngan B; Said, Jonathan W; Loh, Xin-Yi; Xu, Liang; Liu, Li-Zhen; Yang, Henry; Hayano, Takahide; Shi, Shuo; Xie, Dong; Lin, De-Chen; Koeffler, H Phillip. SETDB1 accelerates tumourigenesis by regulating the WNT signalling pathway. The Journal Of Pathology. 2015;235(4):559-70. 

Chen, Bifeng; Wang, Jingdong; Wang, Jieling; Wang, Huan; Gu, Xiuli; Tang, Liang; Feng, Xianhong. A regulatory circuitry comprising TP53, miR-29 family, and SETDB1 in non-small cell lung cancer. Bioscience Reports. 2018;38(5) 

Ceol, Craig J; Houvras, Yariv; Jane-Valbuena, Judit; Bilodeau, Steve; Orlando, David A; Battisti, Valentine; Fritsch, Lauriane; Lin, William M; Hollmann, Travis J; Ferré, Fabrizio; Bourque, Caitlin; Burke, Christopher J; Turner, Laura; Uong, Audrey; Johnson, Laura A; Beroukhim, Rameen; Mermel, Craig H; Loda, Massimo; Ait-Si-Ali, Slimane; Garraway, Levi A; Young, Richard A; Zon, Leonard I. The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. Nature. 2011;471(7339):513-7. 

Rodriguez-Paredes, M; Martinez de Paz, A; Simó-Riudalbas, L; Sayols, S; Moutinho, C; Moran, S; Villanueva, A; Vázquez-Cedeira, M; Lazo, P A; Carneiro, F; Moura, C S; Vieira, J; Teixeira, M R; Esteller, M. Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis. Oncogene. 2014;33(21):2807-13. 

Han, Shuai; Zhen, Wei; Guo, Tongqi; Zou, Jianjun; Li, Fuyong. SETDB1 promotes glioblastoma growth via CSF-1-dependent macrophage recruitment by activating the AKT/mTOR signaling pathway. Journal Of Experimental & Clinical Cancer Research : Cr. 2020;39(1):218.