Anti N(Epsilon)-(Carboxyethyl) Lysine (CEL) mAb (Clone CEL-SP)

Cosmo Bio

SKU: CAC-AGE-M02

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Background

Advanced Glycation End Product (AGE) is a general term for structures generated in the late stage of non-enzymatic glycation reactions (Millard reactions) between reducing sugars and proteins. AGE accumulation is known to be significantly elevated in age-related diseases such as diabetes and arteriosclerosis.

Nε-(carboxyethyl) lysine (CEL) is generated from protein modification by methylglyoxal (MG). MG is enzymatically derived from the Embden-Meyerhof and polyol pathways, through the degradation of glyceraldehyde-3-phosphate (G3P) (Phillips and Thornalley, 1993). Mclellan et al. (McLellan et al., 1994) demonstrated that plasma MG concentration in insulin-dependent diabetic patients was 7-times higher than in healthy individuals. CEL accumulation increases with age in human lens proteins.

Source: Professor Nagai Ryuji, Tokai University Faculty of Agriculture Department of Biosciences Food Bioregulation Research Laboratory

Product description

Package Size	50 µg
Form	Liquid (0.1M NaPB, pH7.0, 20 mg/ml BSA, 0.1% Sodium Azide (NaN3 ) added)
Concentration	1 mg/mL
Purity	Affinity Purified
Host	Rabbit Polyclonal
Immunogen	Synthetic phosphopeptide corresponding to residues L(44)S(p)PFYLRPPSF(54)C of human alpha-B Crystallin
Specificity	Alpha-B crystallin p45S
Cross Reactivity	Bovine, Human, Mouse, Rat
Subclass	IgG
Storage	Store below -20°C. Avoid freeze-thaw cycles.