Anti Aph-1 Homolog A, Gamma-Secretase Subunit (APH1A) pAb (Rabbit, Affinity Purified)

Cosmo Bio

SKU: KAL-KR078

Amyloid ? peptide is known as a causative protein of Alzheimer's disease (AD). This amyloid ? peptide is secreted after the amyloid precursor protein is cut with ?-secretase and ?-secretase. Recently research about ?-secretase is advanced, and it is elucidated that complex constituted by presenilin as the center, nicastrin, PEN-2, and anterior-pharynx defective 1 (APH-1) is ?-secretase. APH-1 is indispensable for ?-secretase activity and is thought to work for stabilization of the complex. ?-secretase is also related to Notch signaling that is important in the process of the development. This antibody was produced using a partial peptide of human APH-1a as an antigen. It does not crossreact with APH-1b that is the homologue. It is expected to be useful to research the mechanism about the onset of AD and the signal transduction. It can be used for Western blotting.

Product Specifications

• Application: WB
• Reactivity: Human
• Clonality: Polyclonal
• Host: Rabbit