Anti Serine/Threonine-Protein Kinase VRK1 mAb (Clone 5D1)

Catalog No:
BAM-71-600-EX
$314.00

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Application: IP, ELISA, IF, IHC, WB, ICC 
Clonality: Monoclonal 
Host: Mouse 
Purification: IgG 
Reactivity: Human 
Western blotting: 1/200-1/1000.

Highly sensitive chemiluminescence reagents such as Lumi-Light Plus (Roche), ImmunoStarRLD, or ImmunoStarR Zeta (Wako, Osaka) are recommended.

Immunoprecipitation: assay dependent

Immunofluorescence staining: 1/100

Immu The VRK1 gene encodes serine/threonine kinase VRK1 (Vaccinia-Related Kinase 1; 396 aa, 45.5 kDa) which is involved in Golgi disassembly during the cell cycle following phosphorylation by PLK3 during mitosis, and required to induce Golgi fragmentation. It acts by mediating phosphorylation of a downstream target protein 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. It also phosphorylates casei and histone H3. Phosphorylation of the BANF1 gene product disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Involvement in disease Defects in VRK1 are the cause of pontocerebellar hypoplasia type 1A (PCH1A); also called pontocerebellar hypoplasia with infantile spinal muscular atrophy or pontocerebellar hypoplasia with anterior horn cell disease. PCH1A is characterized by an abnormally small cerebellum and brainstem, central and peripheralmotor dysfunction from birth, gliosis and anterior horn cell degeneration resembling infantile spinal muscular atrophy.

Cross reactivity: Human VRK1 protein.

Not tested with other species.
Documents & Links for Anti Serine/Threonine-Protein Kinase VRK1 mAb (Clone 5D1)
Datasheet Anti Serine/Threonine-Protein Kinase VRK1 mAb (Clone 5D1) Datasheet

Documents & Links for Anti Serine/Threonine-Protein Kinase VRK1 mAb (Clone 5D1)
Datasheet Anti Serine/Threonine-Protein Kinase VRK1 mAb (Clone 5D1) Datasheet