Anti Transcription Initiation Factor TFIID Subunit 1 (TAF1) pAb (Rabbit, Antiserum)

Cosmo Bio LTD

Catalog No: BAM-70-457EX

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Application: IF, WB, ICC 
Clonality: Polyclonal 
Host: Rabbit 
Purification: Serum 
Reactivity: Hamster, Human, Mouse, Rat 
TAFIID subunit1 (1,872 aa, 213 kDa) is the largest component and core scaffold of the TFIID basal

transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can

autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to

MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses

DNA-binding activity. Essential for progression of the G1 phase of thecell cycle. Application: 1) Western blotting (1/1,000 dilution)

2) Immunofluorescent staining (1/1,000~1/5,000)

Other applications have not been tested

Cross reactivity: Human, hamster, mouse and rat. Not tested in otherspecies

Immunogen: Synthetic peptide of human TFIID subunit 1 protein corresponding to amino acids 103-123,

STEDAVDYSDINEVAEDESRR-C , conjugated with KLH