Anti Nuclear Pore Complex Protein NUP98 mAb (Clone 21A10)

Cosmo Bio LTD

Catalog No: BAM-70-346EX

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Application: ICC, IF, WB 
Clonality: Monoclonal 
Host: Mouse 
Purification: IgG 
Reactivity: S. cerevisiae, Human, S. pombe, Tetrahymena 
Nucleoporin 98 (Nup98) is a component of nuclear pore complex (NPC), which is a large protein assembly

embedded in the nuclear envelope and highly conserved in eukaryotes. It is localized on both nuclear and

cytoplasmic side of NPC.This protein contains glycine-leucine-phenylalanine-glycine (GLFG) amino acid

repeats and plays a critical role in nuclear trafficking. Nup98 also plays a specific role in the RNA export. In

addition, Nup98 plays roles in several important biological events such as gene expression, mitotic checkpoint, and

pathogenesis

Nup98 gene is fused to a variety of partner genes in human myeloid and T-cell malignancies via chromosomal

translocation.

In ciliates, a unicellular organism having two functionally distinct nuclei, GLFG-Nup98 is present in one of the

nuclei and a distinct Nup98 ortholog is present in the other nucleus, and these different Nup98s participate in a

nucleus-selective transport mechanism. Application: 1) Western blotting, (S. cerevisiae, S. pombe,) Not suitable for human. Clone 13C2 is recommended for WB in human Tetrahymena and yeasts.

2) Most suitable for Immunofluorescence staining / Immunocytochemistry for human, Tetrahymena, S. cerevisiae, S. pombe.

Immunogen: Synthetic peptides containing conserved N-terminal sequence, GLFG, of Nup98 protein of

Tetrahymena thermophila.

Peptide 1; 1-MFGNTGGGGLFGNTQTQQTGGGLFGQPQQ-29

Peptide 2; 646-SNPTQGGGLFGAANPGLGG-664

Epitope determined: GLF (Ref.1)

Reactivity: Human, S. cerevisiae, S. pombe and Tetrahymena. Not tested in other species