Anti Nuclear Pore Complex Protein NUP98 mAb (Clone 13C2)

Cosmo Bio LTD

Catalog No: BAM-70-345EX

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Application: ICC, IF, WB 
Clonality: Monoclonal 
Host: Mouse 
Purification: IgG 
Reactivity: S. cerevisiae, Human, S. pombe, Tetrahymena 
Nucleoporin 98 (Nup98) is a component of nuclear pore complex (NPC), which is a large protein

assembly embedded in the nuclear envelope and highly conserved in eukaryotes. It is localized on

both nuclear and cytoplasmic side of NPC.

This protein contains glycine-leucine-phenylalanine-glycine (GLFG) amino acid repeats and

plays a critical role in nuclear trafficking. Nup98 also plays a specific role in the RNA export. In

addition, Nup98 plays roles in several important biological events such as gene expression, mitotic

checkpoint, and pathogenesis

Nup98 gene is fused to a variety of partner genes in human myeloid and T-cell malignancies via

chromosomal translocation.

In ciliates, a unicellular organism havingtwo functionally distinct nuclei, GLFG-Nup98 is present

in one of the nuclei and a distinct Nup98 ortholog is present in the other nucleus, and these

different Nup98s participate in a nucleus-selective transport mechanism. Application: 1) Most suitable for Western blotting, (Human, S. cerevisiae, S. pombe, Tetrahymena. Not tested in

other species)

2) Immunofluorescence staining / Immunocytochemistry for S. cerevisiae, S. pombe and

T.etrahymena. Not suitable for IF in human