Anti Nestin (NES) mAb (Clone 7A3)

Cosmo Bio LTD

Catalog No: BAM-73-100-EX

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Application: IHC(f), ICC, IF 
Clonality: Monoclonal 
Host: Rat 
Purification: IgG 
Reactivity: Mouse 

Background:Nestin is an intermediate filament protein that is expressed in stem cells and progenitor cells in the mammalian central nervous system (CNS) during development. Nestin is replaced in the adult organism by other intermediate filament proteins, however, it may be re-expressed under certain pathological conditions such as ischemia, inflammation, brain injury, and neoplastic transformation. Nestin has been detected in many kinds of tumors, especially in tumors derived from the CNS, therefore it is considered to be a marker for cancer stem cells in neurogenic tumors. Data Link UniProtKB/Swiss-Prot Q6P5H2 (NEST_MOUSE)

References. This antibody has been used in the following publication. . Iriuchishi H. Neovascular niche for human myeloma cells in immunodeficient mouse bone PLoS One. 2012;7(2):e30557. PMID: 22347385 IHC-F (mouse)