Anti DNA Polymerase Eta (POLH) mAb (Clone 5H10)

Cosmo Bio LTD

Catalog No: BAM-70-071EX

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Application: WB, IF, ICC 
Clonality: Monoclonal 
Host: Mouse 
Purification: Ion-exchange Chromatography 
Reactivity: Human 

DNA polymerase eta ( 713 aa, 78 kDa) is specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI (Pol iota) to replication foci.

Immunogen: Human recombinant full-size Pol eta tagged with His6.

Applications: Western blot. Not tested for other application

Reactivity: Human Pol eta protein. Not tested in other species