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Drosophila Reactive Antibodies

NameHostAntigen SpeciesX-reactCloneAppplicationsSize
Anti dCAMKII [ Cat No. CAC-TNL-001-CAM ] MS Drosophila Drosophila 18 WB IHC 100UL
Anti CHICO [ Cat No. COP-COP-080063 ] RAB Drosophila     WB IHC 100UL
Anti FOXO [ Cat No. CAC-THU-A-DFOXO ] RAB   Drosophila   WB IP ChIP 100UL
Anti SSRP1 [ Cat No. CAC-NIG-L1-SHA1 ] RAB Drosophila Drosophila   WB ELISA IHC IP ChIP 100UL
Anti Rhodopsin [ Cat No. LSL-LB-5533 ] RAB   Drosophila/Insect   ELISA IF WB 100UL

 

Drosophila IMD Pathway Inhibitors

NameAlternate NameAplicationsSize
Drosophila Diptericin Inhibitor TPS-17 (E)-3-(c-3,c-4-dihydroxycyclopent-r-1-yl)propenamide in vivo Ind suppression; ex-vivo culture system inhibitor IC50 3 ug/ml 500 ug
Drosophila Diptericin Inhibitor TPS-19 (E)-N-methyl-3-(c-3,c-4-dihydroxycyclopent-r-1-yl)propenamide in vivo Ind suppression; ex-vivo culture system inhibitor IC50 1 ug/ml 500 ug

 

Background
Innate immunity comprises evolutionarily conserved self-defense mechanisms against microbial infections. In mammals, innate immunity interacts with adaptive immunity and has a key role in the regulated immune response. Therefore, innate immunity is a pharmaceutical target for the development of immune regulators. Using Drosophila ex vivo culture systems (Yajima et al. Biochem. J. 371, 205-210, 2003), a cyclopentanediol analogue is isolated from Aspergillus sp. as an immunosuppressive substance (Sekiya et al. Biochem. Pharm. 75, 2165-2174, 2008).

These compounds selectively suppresses activation of the Imd pathway in Drosophila in vivo. The target molecules of the compound lie between the Imd adaptor protein and dTAK1 kinase in the Imd pathway. In human cells, the compound suppresses TNF-a, but not IL-1ß, stimulation-induced activation of NF-kB, suggesting that its target molecules are upstream of TAK1 in mammalian innate immunity. The compounds, TPS-17 and TPS-19, are developed from the cyclopentanediol analogue (Kikuchi et al. Eur.J.Med.Chem 46. 1263-1273, 2011).

drodiptinhib17.jpg drodiptinhib19.jpg
Drosophila Diptericin Inhibitor TPS-17 Drosophila Diptericin Inhibitor TPS-19



REFERENCES

1) M. Yajima, M. Takada, N. Takahashi, H. Kikuchi, S. Natori, Y. Oshima, and S. Kurata: "A Newly Established in Vitro Culture Using Transgenic Drosophila Reveals Functional Coupling between the Phospholipase A2-generated Fatty Acid Cascade and Lipopolysaccharide-dependent Activation of the immune deficiency (imd) Pathway in Insect Immunity" Biochem. J., 371, 205-210 (2003). PMID:12513692

2) M. Sekiya, K. Ueda, K. Okazaki, H. Kikuchi, S. Kurata, and Y. Oshima."A Cyclopentanediol Analogue Selectively Suppresses the Conserved Innate Immunity Pathways, Drosophila IMD and TNF-a Pathways" Biochem. Pharmacol., 75, 2165-2174 (2008). PMID:18417101

3) H. Kikuchi, K. Okazaki, M. Sekiya, Y. Uryu, Y. Katou, K. Ueda, S. Kurata, Y. Oshima: "Synthesis and innate immunosuppressive effect of 1,2-cyclopentanediol derivatives" Eur.J.Med.Chem 46. 1263-1273 (2011). PMID:21334120

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