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Antibodies
TDP-43 (native and phosphospecific)
C9orf72 expansion dipeptide repeats


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Background
TDP-43, a heterogeneous nuclear ribonucleoprotein, was identified as a component of ubiquitin-positive and tau-negative inclusions observed in cases of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). Immunochemical analyses using antibodies generated against phospho- and non-phosphopeptides of human TDP-43 revealed that abnormally phosphorylated full-length TDP-43 (45 kDa), C-terminal fragments (~25 kDa) and smearing substances are deposited as intracellular inclusions in affected regions of FTLD-U and ALS cases. These antibodies are powerful tools for biochemical and immunohistochemical analyses of neurodegenerative diseases and for evaluation of cellular or animal models of TDP-43 proteinopathy.

native

native
phospho
 

Antibodies to Native TDP-43
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Name
(click for more info)
Host Antigen Species X-react Clone Applications Size Cat No (click for datasheet) Cosmo USA Price
Anti TDP-43 (3-12) RAB HU HU/RAT poly WB/ELISA/IHC 100 ul CAC-TIP-TD-P07 $667
Anti TDP-43 (405-414) RAB HU HU/RAT poly WB/ELISA/IHC 100 ul CAC-TIP-TD-P09 $667

Antibodies to Phosphorylated TDP-43
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Background
With 39 antisera to potential phosphorylation sites, Hasegawa et. al. determined that TDP-43 deposited in brain cell inclusions of FTLD-U and ALS patients may become phosphorylated at serines 379, 403/404, 409, 410, 409/410 (1). Characterized for WB, IHC, and ELISA, six of the most relevant antibodies are now available through Cosmo Bio.

1) Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.Hasegawa M, et. al. Ann Neurol. 2008 Jul;64(1):60-70. PMID: 18546284
 
Name
(click for more info)
Host Antigen Species X-react Clone Applications Size Cat No
(click for datasheet)
Cosmo USA Price
Anti TDP-43, phospho Ser409/410 MS HU HU 11-9 WB/ELISA/IHC 50 ul CAC-TIP-PTD-M01 $667
Anti TDP-43, phospho Ser409/410-1 RAB HU HU poly WB/ELISA/IHC 100 ul CAC-TIP-PTD-P01 *discontinued*
recommended substitute:
CAC-TIP-PTD-M01
Anti TDP-43, phospho Ser409/410-2 RAB HU HU poly WB/ELISA/IHC 100 ul CAC-TIP-PTD-P02 $667
Anti TDP-43, phospho Ser409 RAB HU HU poly WB/ELISA/IHC 100 ul CAC-TIP-PTD-P03 $667
Anti TDP-43, phospho Ser410 RAB HU HU poly WB/ELISA/IHC 100 ul CAC-TIP-PTD-P04 $667
Anti TDP-43, phospho Ser403/404 RAB HU HU poly WB/ELISA/IHC 100 ul CAC-TIP-PTD-P05 $667


Dipeptide Repeat Protein Antibodies
Recognizing dipeptide repeat proteins present in p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neuron disease associated with expansions in C9ORF72.
 
Hexanucleotide expansions in C9orf72 gene was identified in patients with Frontotemporal Lober Degeratation (FTLD) and Amyotrophic Lateral Sclerosis (ALS) in 2011. GGGGCC expansions are characterised pathologically by the presence of TDP-43 negative and p62 positive inclusions in granule cells of cerebellum and in cells of dentate gyrus and CA4 area of the hippocampus. It was reported that these inclusions included dipeptide repeat proteins, poly-GA, poly-GR and poly GP, arising from a putative non-ATG initiatedsense translation of the GGGGCC expansion. These antibodies are powerful tools for IHC analysis of neurodegenerative diseases.

Reference: Mann DM, et. al., Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72.Acta Neuropathol Commun. 2013 Oct 14;1(1):68. PMID: 24252525
Name
(click for more info)
Host Antigen Species X-react Clone Applications Size Cat No
(click for datasheet)
Cosmo USA Price
Anti C9orf72 (Poly-GA) RAB HU HU polyclonal ELISA/IHC 50UL CAC-TIP-C9-P01 $534
Anti C9orf72 (Poly-GR) RAB HU HU polyclonal ELISA/IHC 50UL CAC-TIP-C9-P02 $534
Anti C9orf72 (Poly-GP) RAB HU HU polyclonal ELISA/IHC 50UL CAC-TIP-C9-P03 $534

AS170414

 

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