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Antibodies
Neurodegeneration Related

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Note: This list represents selected products. To search all available antibodies, see the Antibodies A-Z list.
Amyloid-β Antibodies                  
Name
(click name for more info)

Host
Antigen Species
X-react
Clone
Applications
Size
Cat. No.
(click for datasheet)
CBU Price
Amyloid β-peptide 40 (Aβ40)             1MG CSR-KN-TOYU-M03 $443
Amyloid β-peptide 42 (Aβ42)             1MG CSR-KN-TOYU-M04 $608
Amyloid β-peptide 42 (Aβ42), TAMRA conjugated             0.5MG PMC-AK13-COS $768
Anti APP (amyloid-β precursor protein)   MS   HU 278 WB ELISA 100UG CAC-YCU-MK-AP01 $443
Ant-Amyloid-β   MS   HU 59 WB ELISA 100UG CAC-YCU-MK-BA01 $443
Anti Amyloid-β (1-40)   RAB HU HU   IHC EIA 50UL YII-YA010-EX $443
 

C9orf72 (Dipeptide Repeat) Antibodies
Hexanucleotide expansions in C9orf72 gene was identified in patients with Frontotemporal Lober Degeratation (FTLD) and Amyotrophic Lateral Sclerosis (ALS) in 2011. GGGGCC expansions are characterised pathologically by the presence of TDP-43 negative and p62 positive inclusions in granule cells of cerebellum and in cells of dentate gyrus and CA4 area of the hippocampus (1). It was reported that these inclusions included dipeptide repeat proteins, poly-GA, poly-GR and poly GP,arising from a putative non-ATG initiatedsense translation of the GGGGCC expansion.

(1) Mann DM, et. al., Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72.Acta Neuropathol Commun. 2013 Oct 14;1(1):68. PMID: 24252525

Name
(click name for more info)

Host
Antigen Species
X-react
Clone
Applications
Size
Cat. No.
(click for datasheet)
CBU Price
Anti C9orf72 (Poly-GA)   RAB HU HU   ELISA IHC 50UL CAC-TIP-C9-P01 $443
Anti C9orf72 (Poly-GP)   RAB HU HU   ELISA IHC 50UL CAC-TIP-C9-P03 $443
Anti C9orf72 (Poly-GR)   RAB HU HU   ELISA IHC 50UL CAC-TIP-C9-P02 $443

                   
GFAP Antibodies
Name
(click name for more info)

Host
Antigen Species
X-react
Clone
Applications
Size
Cat. No.
(click for datasheet)
CBU Price
Anti GFAP   RAB HU HU MS RAT   WB IHC(p) 0.2ML SML-ROI003-EX $331

                   
Humanin Antibodies
Anti Humanin   RAB HU HU   WB 25UG KAL-KR050 $542
Anti S14G-Humanin   RAB HU HU   WB 25UG KAL-KR061 $542
Anti Humanin   RAB HU HY   IHC EIA 50 ul YII-Y440-EX $387

 
Synuclein Antibodies
Name
(click name for more info)

Host
Antigen Species
X-react
Clone
Applications
Size
Cat. No.
(click for datasheet)
CBU Price
Anti-α-synuclein   SHP HU HU   IHC(f) IHC(p) WB IF LM 0.1ML ATA-CB-AS2S $651
Anti-α-synuclein   SHP HU HU   IHC(f) IHC(p) WB IF LM 0.1ML ATA-CB-AS1S $651
Anti-α-synuclein   SHP HU HU   IHC(f) IHC(p) WB IF LM 0.1ML ATA-CB-AS3S $651
Epitope Specific α-Synuclein Antibodies                
Anti-α-Synuclein (aa 1-10)   RAB   HU   IHC WB 50UL CAC-TIP-SN-P01 $443
Anti-α-Synuclein (aa 11-20)   RAB   HU   IHC WB 50UL CAC-TIP-SN-P02 $443
Anti-α-Synuclein (aa 21-30)   RAB   HU   IHC WB 50UL CAC-TIP-SN-P03 $443
Anti-α-Synuclein (aa 31-40)   RAB   HU   IHC WB 50UL CAC-TIP-SN-P04 $443
Anti-α-Synuclein (aa 41-50)   RAB   HU   IHC WB 50UL CAC-TIP-SN-P05 $443
Anti-α-Synuclein (aa 51-60)   RAB   HU   IHC WB 50UL CAC-TIP-SN-P06 $443
Anti-α-Synuclein (aa 61-70)   RAB   HU   IHC WB 50UL CAC-TIP-SN-P07 $443
Anti-α-Synuclein (aa 75-91)   RAB   HU   IHC WB 50UL CAC-TIP-SN-P08 $443
Anti-α-Synuclein (aa 131-140)   RAB   HU   IHC WB 50UL CAC-TIP-SN-P09 $443
Anti-α-Synuclein (9 antibodies set)   RAB   HU   IHC WB 9*10UL CAC-TIP-SN-SET $992

                 
Ant-β-synuclein   SHP HU HU   IHC(f) IHC(p) IF LM 0.1ML ATA-CB-BS1S $651
Anti-γ-synuclein   SHP HU HU   IHC(f) WB 0.1ML ATA-CB-GS1S $651

                 
Paraoxonase (PON) Antibodies
Name
(click name for more info)

Host
Antigen Species
X-react
Clone
Applications
Size
Cat. No.
(click for datasheet)
CBU Price
Anti PON1   MS HU HU 4C2 WB 100UG CAC-ABN-M02-HP $552
Anti PON1   MS MS MS   WB 100UG CAC-ABN-M03-MP $552

 
Prion Antibodies
Name
(click name for more info)

Host
Antigen Species
X-react
Clone
Applications
Size
Cat. No.
(click for datasheet)
CBU Price
Anti Prion, clone 2C5-5   MS HU HU 2C5-5 WB ELISA 250UG BAM-65-902-EX $992
Anti Prion, clone 2C5-5   MS HU HU 2C5-5 WB ELISA 50UG BAM-65-901-EX $331
Anti Prion, clone 7A1   MS HU HU 7A1 WB ELISA 250UG BAM-65-904-EX $992
Anti Prion, clone 7A1   MS HU HU 7A1 WB ELISA 50UG BAM-65-903-EX $331
Anti Prion Protein A   RAB BOV HU MS RAT BOV SHP   ELISA IF WB 100UL LSL-LB-3117 $552
Anti Prion Protein B   RAB BOV HU MS RAT BOV SHP   ELISA IF WB 100UL LSL-LB-3227 $552

 
Tau Antibodies
Tau is a microtubule-associated protein. In adult human brain, 6 tau isoforms are expressed, which are divided into two groups, 3-repeat (3R) and 4-repeat (4R) tau isoforms. Tau assembles into insoluble, filamentous, and hyperphosphorylated inclusions in many neurodegenerative diseases, and different tau isoforms are accumulated in the diseased brains, namely, 6 tau isoforms in AD, 3R tau isoforms in Pick’s disease, and 4R tau isoforms in PSP and CBD. Therfore, isoform-specific tau antibodies are useful tools for immunohistochemical and biochemical studies of tau species in diseased brains. Tau deposited in AD is extensively deamidated at N279. This anti-4R specifically recognizes 4R tau isoforms regardless of deamidation and strongly stained tau in AD brain.
Name
(click name for more info)

Host
Antigen Species
X-react
Clone
Applications
Size
Cat. No.
(click for datasheet)
CBU Price
Anti 4R-tau   RAB HU HU MS RAT   WB IHC 50UL CAC-TIP-4RT-P01 $667
Anti Tau, phospho Ser416   RAB HU HU RAT   IHC 25UG KAL-KR076 $542
The following tau antibodies achieve excellent staining of Tau aggregations within neurons (tangles), distrophic neurons within plaques, and Tau threads within axons. These antibodies also detect multiple Tau isoforms on Western blotting. See datasheets for pictures.
Anti Tau   SHP HU HU   IHC(f) IHC(p) IF LM 0.2ML ATA-CB-TAUSB $1,158
Anti Tau   SHP HU HU   IHC(f) IHC(p) IF LM 0.1ML ATA-CB-TAUSA $651
Anti Tau   RAB HU HU   IHC(f) IHC(p) IF LM 0.2ML ATA-CB-TAURB $1,158
Anti Tau   RAB HU HU   IHC(f) IHC(p) IF LM 0.1ML ATA-CB-TAURA $651

 
TDP-43 Antibodies
TDP-43, a heterogeneous nuclear ribonucleoprotein, was identified as a component of ubiquitin-positive and tau-negative inclusions observed in cases of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). Immunochemical analyses using antibodies generated against phospho- and non-phosphopeptides of human TDP-43 revealed that abnormally phosphorylated full-length TDP-43 (45 kDa), C-terminal fragments (~25 kDa) and smearing substances are deposited as intracellular inclusions in affected regions of FTLD-U and ALS cases. These antibodies are powerful tools for biochemical and immunohistochemical analyses of neurodegenerative diseases and for evaluation of cellular or animal models of TDP-43 proteinopathy.
Name
(click name for more info)

Host
Antigen Species
X-react
Clone
Applications
Size
Cat. No.
(click for datasheet)
CBU Price
Native Antibodies                  
Anti TDP-43 (3-12)   RAB HU HU RAT   WB ELISA IHC 100UL CAC-TIP-TD-P07 $667
Anti TDP-43 (405-414)   RAB HU HU RAT   WB ELISA IHC 100UL CAC-TIP-TD-P09 $667
With 39 antisera to potential phosphorylation sites, Hasegawa et. al. determined that TDP-43 deposited in brain cell inclusions of FTLD-U and ALS patients may become phosphorylated at serines 379, 403/404, 409, 410, 409/410 (2). Characterized for WB, IHC, and ELISA, six of the most relevant antibodies are now available through Cosmo Bio.

(2) Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.Hasegawa M, et. al. Ann Neurol. 2008 Jul;64(1):60-70. PMID: 18546284
Phospospecific Antibodies                  
Anti TDP-43, phospho Ser403 404   RAB HU HU   WB ELISA IHC 100UL CAC-TIP-PTD-P05 $667
Anti TDP-43, phospho Ser409   RAB HU HU   WB ELISA IHC 100UL CAC-TIP-PTD-P03 $667
Anti TDP-43, phospho Ser409 410   MS HU HU 11-9 WB ELISA IHC 50UL CAC-TIP-PTD-M01 $667
Anti TDP-43, phospho Ser409 410, pAb 1   RAB HU HU   WB ELISA IHC 100UL CAC-TIP-PTD-P01 *discontinued*
recommended substitute:
CAC-TIP-PTD-M01
Anti TDP-43, phospho Ser409 410, pAb 2   RAB HU HU   WB ELISA IHC 100UL CAC-TIP-PTD-P02 $667
Anti TDP-43, phospho Ser410   RAB HU HU   WB ELISA IHC 100UL CAC-TIP-PTD-P04 $667

 
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