What's up.doc,  No. 90,  "Product Showcase 4" 
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More Cool Biotools from Japan         

 Neuroendocrine Research

CRF ELISA, high sensitivity
 

Highly specific for the sensitive quantification of mouse or rat CRF in plasma and brain tissue extracts.  In this sandwich ELISA, CRF in sample is captured by immobilized anti-CRF antibody and is detected with biotin-labeled anti-CRF antibody, peroxidase-streptavidin and peroxidase substrate TMB. 
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Protein Turnover

Anti Siah Antibodies


 
The Siah1 and Siah2 RING finger type E3 ligases are mammailian homologs of the Drosophila Sevenless in Abstentia gene involved in development of the R7 photoreceptor. Siah proteins are involved in the ubiquitin and proteosome mediated degredation of several proteins, while Siah1 is a central component of a multiprotein E3 ubiquitin ligase complex that targets beta catenin for destruction in response to p53 activation.
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HIV Research

Anti HIV-1 Gag p24 Antibody


              
The HIV-1 p24 gag protein constitutes the core of the HIV-1 capsid. This rabbit antibody was produced by immunizing with a recombinant p24 protein overexpressed (HIV-1,  subtype B) and purified from E. coli and highly purified by several rounds of chromatography. In western blots of lysates from HIV-p24 and p55 and p41 precursors. 

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Hepatocyte Differentiation

Anti CYP7A1 antibody



CYP7A1 (Cytochrome P450, Family 7, Superfamily A, Polypeptide 1) is a highly specific marker for hepatocytes. Expression of CYP7A1 (cholesterol 7-alpha hydroxylase) is restricted to mature hepatocytes and not expressed in yolk sac or cells of extra-hepatic origin. CYP7A1 expression has been used to show hepatic differentiation in embryoid bodies derived from mouse embryonic stem cells.
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Endocrine Research

Rat C-Peptide EIA



C-peptide and insulin are produced in stoichiometric amounts from the cleavage for proinsulin. Cosmo Bio offers several kits for quantitative determination of C-peptide in plasma, serum, and urine samples. The C-peptide in these samples is detected without interference from other factors. 
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Liver Metabolism 

Assay for Liver X Receptor


The LXR nuclear receptor plays an important role in cholesterol regulation and fatty acid homeostasis. Thus, LXR is an interesting target for drug development. In contrast to competitive assay systems employing only the nuclear receptor, the RCAS LXR Assay System is designed to assess the influence of potential ligands on the binding reaction between LXRa and the SRC1 co-activator peptide.
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Immunodetection

Can Get Signal Immunoreaction Enhancer



Simply use Can Get Signal solution as an antibody diluent for westerns, ELISAs, dot blots, etc. Can Get Signal dramatically increases signal to noise ratios in many systems. Compatible with colorimetric, chemiluminescent, and fluorescent detection methods. Enzyme labeled antibodies are not disturbed. Trial Size includes one solution specifically for primary antibodies, and one specifically for secondary antibodies.
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Cell Culture Substrate 

CELLYARD Beads



Nylon beads coated with the calcium phosphate compound hydroxyapatite to produce carrier beads with outstanding biocompatibility and optimal features for  suspension cell culture. CELLYARD beads are available in two sizes, with average particle diameters of 200 or 500 microns.

DISCONTINUED

Totally Unique Transfection Alternative  

GenomOne-Neo


Utilizes the membrane fusion properties of HVJ (Sendai virus) envelope to transfect cells with DNA, RNA or proteins. Over 100 references in vivo and in vitro. Great for  siRNA.
  
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About Cosmo Bio

Cosmo Bio USA is the exclusive US distributor for Cosmo Bio Co., Ltd. (Tokyo), bringing you select reagents and small instruments for life science research from Japan. With well over 1,000 products from more than 40 Japanese manufacturers and academic labs, Cosmo Bio conveniently consolidates a wide range of routine and highly unique biotools including over 1,000 antibodies, ELISA and assay kits, and much more. Many products from Cosmo Bio have previously been unavailable commercially or outside of Japan. 

For over 25 years, Cosmo Bio has been fully committed to exceeding customer expectations by providing quality products and the highest standards of customer care and support. 

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