Product Showcase 23

UV Radiation

DNA Damage Monoclonals

Prolonged exposure to solar UV radiation may result in acute and chronic health effects on the skin, eye, and immune system. These harmful effects are suggested to relate to DNA damage. The major types of DNA damage induced by UV radiation are cyclobutane pyrimidine dimers (CPDs), 6-4 photoproducts (6-4PPs), and Dewar photoproducts (DewarPPs). Cosmo Bio offers well characterized monoclonal antibodies specific for these DNA lesions.
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Glycation Research

Anti AGEs

The products of nonenzymatic glycation and oxidation of proteins, lipids, and nucleic acids, advanced glycation end-products (AGEs), accumulate in various pathological conditions, such as diabetes, inflammation, renal failure, and aging. This antibody, clone 6D12, idenifies AGEs modified proteins in human tissues in IHC, Western blot, and ELISA applications.
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Stem Cell Research

Nanog Polyclonals

Pluripotential cell-specific Nanog is expressed in early embryos and stem cells including mouse and human embryonic stem (ES) and embryonic germ (EG) cells. It is a key molecule involved in the signaling pathway for maintaining the capacity for self-renewal and pluripotency, by bypassing the STAT3 pathway. Polyclonals against human and mouse nanog are available.
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Endocrine Research

Glucagon EIA

Specifically measure pancreatic glucagon in human, rat, or mouse plasma with this highly advantageous kit utilizing antibody to the glucagon C-terminal region. Cosmo also offers a range of related ELISA kits and antibodies including GLP-1, GLP-2, and Glicentin.
20% off until August 31, 2010
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In vitro Protein Synthesis

Puresystem

Recostituted from over 30 HIS-tagged components and purified E. coli ribosomes, the PURESYSTEM line of cell-free transcription/translation kits lets you purify native or tagged proteins in just 2-3 hours by negative purification using metal affility chromatography. Lysate free PURESYSTEM virtually eliminates degradation by nucleases and proteases. Kits for synthesis under reducing and oxidizing conditions also available.
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DNA Damage

8-OHdG ELISA kits

Cosmo Bio's 8-OHdG kits are highly specific and highly sensitive and not cross reactive to 19 8-OHdG analogues. These kits can detect 8-OHdG DNA adducts in tissue, serum, and urine samples. Assays can be completed in as little as 3.5 hours.
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mAb Adjuvant

Synthetic Pristane

The isoprenoid alkane Pristane has found several important applications in medical research and biotechnology including the induction of autoimmune and arthritis symptoms in rodents, the induction of rodent plasmacytomas with properties similar to those of multiple myeloma patients, and as an adjuvant for preconditioning the peritoneal cavity of mice and rats to increase production of ascites fluid following injection of hybridoma cells for the isolation of monoclonal antibodies.

Until recently the primary commercial feedstock for pristane has been shark liver oil. However, following the protection of the Basking Shark, the availability of natural pristane has decreased sharply. Synthetic pristane is available from Cosmo Bio to support these important research and commercial applications.
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Glycation Research

Carboxymethyl lysine ELISA

Advanced Glycation Endproducts (AGEs) play an improtant role in age-related pathologies, atherosclerosis, and diabetes. N-(Carboxymethyl) lysine (CML) is one of the best characterized AGEs formed on proteins by glycoxidation or lipid peroxidation pathways. CML modifications on proteins can serve as biomarkers of oxidative stress resulting from sugar and lipid oxidation. This kit detects human CML in cell culture supernatant, plasma, and serum samples.
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Totally Unique Transfection Alternative

GenomOne-Neo

Utilizes the membrane fusion properties of HVJ (Sendai virus) envelope to transfect cells with DNA, RNA or proteins. Over 100 references in vivo and in vitro. Great for siRNA.
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