What's up.doc,  No. 168  "Product Showcase 22" 
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**Special Offers to Cosmo Bio USA Customers**
25% off Histone H3 Monoclonals
until June 30, 2010

20% off Unique Cell/Tissue Culture Tools
until June 30, 2010
 
20% off Biomarker kits & antibodies
until August 31, 2010

Inventory Clearance Specials
While supplies last

Oxidative Stress

Anti Acrolein




Acrolein (ACR) is a representative carcinogenic aldehyde found ubiquitously in the environment and formed endogenously through oxidation reactions, such as lipid peroxidation and myeloperoxidase catalyzed amino acid oxidation. ACR is a highly reactive aldehyde and reacts with lysine residues in proteins. This antibody is specific for ACR modified protein, especially formyl-dehydropiperidino-lysine.

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Membrane Transport  

Anti CD298

 
 
CD298 (Na/K-ATPase beta3) is a 42kDa glycoprotein expressed in a variety of tissues. In the retina, CD298 is involved in synaptic activity and action potential. In human CD298 is involved in regulation of T and B lymphocyte proliferation. This antibody is useful for FCM, IP, and IHC.

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Lysine labeling

STELLA+ Kit



STELLA+ Lysine Labeling Kit selectively labels the lysine residue of proteins or the lysine residue and ethanol amine localized on the cell surface.  Unlike conventional labeling with succinimidyl ester, this kit is capable of rapid and efficient labeling at low concentration by 6pi-Azaelectrocyclization reaction of hexatriene-beta-carbonyl compound.
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Endocrine Research

Rat Leptin-HS ELISA 



Leptin is secreted from white adipose tissue and acts on the hypothalamus to decrease food intake and to reduce body weight, body fat, blood sugar and insulin. The level of leptin in human plasma correlates with tissue fat weight and may be used as an index of obesity.
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Bone Research

Osteocalcin/Bone gla protein ELISA





Osteocalcin is a noncollagenous protein found in bone and dentin. It is secreted by osteoblasts and thought to play a role in mineralization and calcium ion homeostasis. It is often used as a biomarker of bone formation and may be useful for studying the effectiveness of osteoporosis drugs. 
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           Cryopreservation   

FERTIUP Reagents



FERTIUP Mouse Sperm Cryoprotectant  and FERTIUP Mouse Sperm Preincubation Medium are novel and effective solutions for mouse sperm cryopreservation and in vitro fertilization. These reagents facilitate IVF of frozen sperm from C57BL/6J mice.
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Autophagy Research
 
Autophagy Antibodies




Autophagy is the primary means for the degredation of cytoplasmic constituents in the lysosome and has been considered to be an important defensive mechanism during starvation. Atg5, Atg12, Atg16L form an 800kDa protein complex in the cytosol and plays an essential role in membrane elongation. Atg5 KO studies suggest autophagy's role in intracellular protein quality control and killing of intracellular pathogens. 
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Mitochondrial Membrane 

Anti Slc25a19



Slc25a19, also known as DNC, TPC, MUP1, belongs to mitochondrial membrane carrier superfamily and contains three typical mitochondrial inner mitochondrial membrane motifs. In studies using mice, Slc25a19 deletion causes mitochondrial thiamine pyrophosphatase depletion, embryonic lethality, CNS malformations, and anemia.
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Totally Unique Transfection Alternative  

GenomOne-Neo


Utilizes the membrane fusion properties of HVJ (Sendai virus) envelope to transfect cells with DNA, RNA or proteins. Over 100 references in vivo and in vitro. Great for  siRNA.   
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About Cosmo Bio

Cosmo Bio USA is the exclusive US distributor for Cosmo Bio Co., Ltd. (Tokyo), bringing you select reagents and small instruments for life science research from Japan. With well over 1,000 products from more than 40 Japanese manufacturers and academic labs, Cosmo Bio conveniently consolidates a wide range of routine and highly unique biotools including over 1,000 antibodies, ELISA and assay kits, and much more. Many products from Cosmo Bio have previously been unavailable commercially or outside of Japan. 

For over 25 years, Cosmo Bio has been fully committed to exceeding customer expectations by providing quality products and the highest standards of customer care and support. 

Orders and Inquiries
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