What's up.doc,  No. 166  "Product Showcase 21" 
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**Special Offers to Cosmo Bio USA Customers**
25% off Histone H3 Monoclonals

until June 30, 2010

20% off Unique Cell/Tissue Culture Tools
until June 30, 2010
 

Inventory Clearance Specials
While supplies last

Neurodegeneration

Anti phospho TDP-43



TDP-43 is a heterogeneous nuclear ribonucleoprotein identified as a component of ubiquitin-positive and tau-negative inclusions in FTLD-U and ALS. These antibodies are powerful tools for biochemical and immunohistochemical analysis of neurodegenerative diseases and for evaluating cellular and animal models of TDP-43 proteinopathy.
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AA Transporter 

Anti CD98hc (4F2)

 
 

CD98 is a widely expressed cell surface heterodimeric protein composed of a common type II transmembrane heavy chain and one of six light chains. CD98hc is a multifunctional glycoprotein, highly expressed on proliferating lymphocytes, tumor cells and rapidly growing cells. This antibody is specific to human CD98hc and is useful in FCM and IP.

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Protein Labeling

CloverDirect



CloverDirect tRNA Reagents for Site-directed protein functionalization allows the incorporation of unnatural amino acids (fluorescent groups, biotin, PEG, etc.) at defined positions of proteins using in vitro translation. Labeling is accomplished in a few hours using CloverDirect tRNAs that recognize the amber stop codon (UAG) or four base codon (CGGG). 
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Endocrine Research

Rat GLP-2 EIA 



Tissue-specific post-translational processing of proglucagon in the L cells produces glucagon-like peptide-1 (GLP-1), GLP-2, glicentin, and oxyntomodulin. GLP-2 has recently been found to cause intestinal epithelial proliferation. This EIA kit is used for quantitative determination of rat GLP-2 in serum or plasma. Human and Mouse kits are also available.
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Intestinal Research

Rat Diamine Oxidase ELISA






Diamine oxidase (DAO) is an enzyme synthesized primarily in the cells of the gastrointestinal mucosa. Serum levels of DAO have been used as an indicator of the integrity and /or functional mass of the intestinal mucosa. The enzyme is also produced by the placenta and is elevated in newborn serum. 
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           Calcium Channel   

Anti Trpc3




Trpc3 is thought to form a receptor activated non-selective calcium permeant cation channel. Trpc3 is activated by diacylglycerol (DAG) independently of protein kinase C and by inositol-1,4,5-triphosphate receptors with bound IP3. Trpc3 may also be activated by internal calcium store depletion.
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Thrombosis Marker
 
TpP ELISA




Thrombus precursor protein (TpP), which measures soluble fibrin is a marker of active thrombosis. After thrombin cleaves fibrinopeptide A and B from fibrinogen, desAABB fibrin monomers are formed. These monomers polymerize into soluble TpP fibrin polymers, which serve as the immediate precursors to insoluble fibrin.
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Glycobiology 

Fluoresceinamine Heparin


Heparin is a sulfated glycosaminoglycan composed of repeating disaccharide units. Heparin is abundant in mast cells of intestine or lung and exists as unbranched polysaccharide chains. This product is prepared by the fluorescent labeling of Heparin derived from porcine intestine.
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Totally Unique Transfection Alternative  

GenomOne-Neo


Utilizes the membrane fusion properties of HVJ (Sendai virus) envelope to transfect cells with DNA, RNA or proteins. Over 100 references in vivo and in vitro. Great for  siRNA.   
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About Cosmo Bio

Cosmo Bio USA is the exclusive US distributor for Cosmo Bio Co., Ltd. (Tokyo), bringing you select reagents and small instruments for life science research from Japan. With well over 1,000 products from more than 40 Japanese manufacturers and academic labs, Cosmo Bio conveniently consolidates a wide range of routine and highly unique biotools including over 1,000 antibodies, ELISA and assay kits, and much more. Many products from Cosmo Bio have previously been unavailable commercially or outside of Japan. 

For over 25 years, Cosmo Bio has been fully committed to exceeding customer expectations by providing quality products and the highest standards of customer care and support. 

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