Product Showcase 19

mAb Adjuvant

Synthetic Pristane

The isoprenoid alkane Pristane has found several important applications in medical research and biotechnology including the induction of autoimmune and arthritis symptoms in rodents, the induction of rodent plasmacytomas with properties similar to those of multiple myeloma patients, and as an adjuvant for preconditioning the peritoneal cavity of mice and rats to increase production of ascites fluid following injection of hybridoma cells for the isolation of monoclonal antibodies.

Until recently the primary commercial feedstock for pristane has been shark liver oil. However, following the protection of the Basking Shark, the availability of natural pristane has decreased sharply. Synthetic pristane is available from Cosmo Bio to support these important research and commercial applications.
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Apoptosis

Anti GPR65

GPR65 is a member of a G-protein coupled receptor which is up-regulated during the programmed cell death of T-lymphocytes. It is mainly expressed in lymphoid organs including the peripheral blood leukocytes, spleen, thymus, lymph nodes, and cancer tissues. GPCR65 is one of the proton-sensing GPCR that is a receptor for psychosine and its related lysosphingolipids.
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DNA Recombination

Anti Rhp51p

Rhp51 protein of S. pombe is a functional and structural homolog of E. coli RecA and Rad51 proteins of eukaryotes and plays a role in genetic recombination and repair by mediating strand exchange reaction between homologous DNA strands. The product was prepared by immunizing rabbit with full-length purified, recombinant Rhp51.
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Transcriptional Regulation

Histone H3 Monoclonals

Described by Kimura et al. in 2008 (PMID: 18227620), Cosmo Bio is please to offer these antibodies to Histone H3 modifications including methylation, acetylation, and phosphorylation. These versatile, highly reliable, cross-characterized panel of Histone H3 mouse monoclonals are useful for ChIP, immunoblotting, or immunostaining applications and are available in a smaller 20ul trial size.
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Glycobiology

Labeled Chondroitin Sulfate

These products are prepared by fluorescent labeling of chondroitin sulfate derived from whale cartilage, shark cartilage, or squid cartilage. Fluoresceinamine molecules (490-500nm EX/ 515-525nm EM) are chemically attached to carboxyl groups of the glucuronic acid of CS. The solutions are dissolved in PBS and filter sterilized.
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Glycation Research

Anti AGE-4

The products of the nonenzymatic glycation and oxidation of proteins, lipids, and nucleic acids, known as advanced glycation endproducts (AGEs), accumulate in various pathological conditions such as diabetes, inflammation, renal failure, atherosclerosis, Alzheimers disease, and aging, This antibody is specific for AGE-4 and will be useful to reaseach in diabetes.
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Transcriptional Regulation

Anti EID1

EID1 encodes a 21kDa protein which interacts with RB1 and EP300 and acts as a repressor of MYOD1 transcription by inhibiting EP300 and CBP histone acetyltransferase activity. It may be invloved in coupling cell cycle exit to the transcription of genes required for cellular differentiation.
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Cytokine Research

IL-6 ELISA

Interleukin6 (IL6) acts as both a pro inflammatory and anti inflammatory cytokine. It is secreted by T-cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. IL-6's role as an anti inflammatory cytokine is mediated through its inhibitory effects on TNF-alpha and IL-1 and activation of IL-1ra and IL-10. This assay measures human IL-6, other species and Interleukin targets are also available.
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Totally Unique Transfection Alternative

GenomOne-Neo

Utilizes the membrane fusion properties of HVJ (Sendai virus) envelope to transfect cells with DNA, RNA or proteins. Over 100 references in vivo and in vitro. Great for siRNA.
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