What's up.doc,  No. 127  "Product Showcase 14"          Cosmo Bio Home                                            Products                                            New Products                             Order/Contact **Special Offers to Cosmo Bio Customers** *PURESYSTEM: Cell-free Protein Synthesis System 15% Discount Until December 28, 2009 *Human Collagen Type 1 ELISA kit Save 37%  Until December 28, 2009 *Inventory Clearance Specials for USA Customers only While supplies last  Neurobiology Homer Antibodies    In neurons, Homer acts as an adaptor protein for several synaptic molecules. Homer is identified to link multiple targets including type1 metabotropic glutamate receptors, IP3 receptors, and shank. The anti-Homer antibodies offered by Cosmo Bio recognize human, mouse, and rat Homer and can be used in Western blot and IHC applications to study the morphology and function of the postsynapse.  Based on native expression patterns, anti-Homer 1, 2, and 3 will distinguish cell types, while anti-Homer Pan detects all cell types where Homer is expressed. View Website Tumor Research  Anti PEDF     Pigment Epithelium-Derived Factor (PEDF) is structurally related to serpine protease inhibitors (serpins) but lacks protease inhibitor activity, the 50kDa secreted glycoprotein is a highly potent inhibitor of tumor angiogenesis in several tumor models and widely studied as a potential therapeutic. PEDF is also noted for inducing extensive neuronal differentiation and for its neurotrophic activity. This IgG1 monoclonal antibody readily detects PEDF in the supernatant of cultured retinal pigment epithelial cells. View Website Plant Research Anti Membrane H+ATPase Electrical potential and pH gradients across plant plasma membranes are maintained in part by H+ATPase proton pumps. This rabbit polyclonal antibody was raised against a peptide corresponding to amino acids 690-704 of the plasma membrane H+ATPase from Arabidopsis thalinia and redily detects H+ATPase in crude membrane preparations by Western blotting. Please visit our website for antibodies against many other plant transporter families.  View Website Transcription Research Psoralin-Biotin-Delivery Conjugate  Visualize DNA topology in vivo, without detergent pretreatment! Using this unique reagent (and a fluorescent streptavidin conjugate) unconstrained negative supercoils (indicative of transcriptional activity) can be visualized and counted in cultured cells, tissue slices, or dissected tissues. Incorporation of an HIV I tat protein-delivery peptide into the reagent enables rapid and efficient uptake by cells without the need for detergent treatment. View Website           Environmental Estrogen 17beta-Estradiol ELISA Due to its estrogenic effects on male animals, 17beta-estradiol is considered an important pollutant of environmental water. Highly specific and sensitive, this easy to use kit offers a convenient means to quantiate 17beta-estradiol in water or cell culture. The well-characterized kit utilizes a competitive immunoassay format in shich the maximal binding of biotin labeled 17beta-setradiol to specific antibody is inhibited by 17beta-estradiol in your samples. View Website IHC Tool    Pap Pen Liquid blocker       Confine liquids to discreet areas on glass slides by drawing hydrophobic boundries with PAP Pen Super Liquid Blocker. Minimize the volume of antibody and other valuable reagents needed during all immunohistochemical procedures. Writes light blue/green. Washes off with xylene. Keep several around your lab.   View Website IHC Accessorie   Multipurpose Incubation Chamber These stackable chambers are ideal whenever a humidified environment is required for slide incubations or slide storage. Removable glass rods elevate samples. Absorbant black filter paper pads provide for moist keeping and high-contrast viewing. Close fitting lid with wide rubber gasket prevents evaporation. Weighty plastic construction. Much more than a box, in clear or orange plastic for UV sensitive applications. Two sizes available for 10 or 20 slides. View Website Histone Methylation  Anti ASH2L ASH2L is a component of the Set1/Ash2 histone methyltransferase (HMT) complex that specifically methylates Lys-4 of histone H3 in the absence of neighboring methylated Lys-9. Mab clone 2046D2a functions for Western and dot blotting, flow cytometry, and immunocytochemistry. View Website Totally Unique Transfection Alternative   GenomOne-Neo Utilizes the membrane fusion properties of HVJ (Sendai virus) envelope to transfect cells with DNA, RNA or proteins. Over 100 references in vivo and in vitro. Great for  siRNA.    View Website

About Cosmo Bio Cosmo Bio USA is the exclusive US distributor for Cosmo Bio Co., Ltd. (Tokyo), bringing you select reagents and small instruments for life science research from Japan. With well over 1,000 products from more than 40 Japanese manufacturers and academic labs, Cosmo Bio conveniently consolidates a wide range of routine and highly unique biotools including over 1,000 antibodies, ELISA and assay kits, and much more. Many products from Cosmo Bio have previously been unavailable commercially or outside of Japan.  For over 25 years, Cosmo Bio has been fully committed to exceeding customer expectations by providing quality products and the highest standards of customer care and support.  Orders and Inquiries USA orders ship directly from Cosmo Bio USA , Inc  in Carlsbad, CA (San Diego County).

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