What's up.doc,  No. 109  "Product Showcase 7" 
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More Cool Biotools from Japan         

 Neuronal Research 

Anti Prion Protein Antibody


  

Variants of human prion proteins (PrP) are associated with transmissible neuro-degenerative spongiform encephalopathies. Mouse monoclonal antibodies 2C5-5 (IgG1,k) and 7A1 (IgG1,k) were prepared using a recombinant human PrP immunogen lacking the glycophosphotidylinosotol (GPI) membrane anchor, expressed and purified from a rabbit kidney cell line.
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Inflammation Research

Anti Macrophage Antibodies
 


   
 

Identify, discriminate, and characterize macrophage and macrophage-related cell types by immunohistochemistry across a range of species with these widely used monoclonal antibodies.
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Oxidative Stress

Anti Dibromo-Tyrosine Antibody




              



Halogenated tyrosines are known to form in granulocytes through the action of peroxidase enzymes and are potenital biomarkers of immune reactivity and inflammation. Reactivity analysis of monoclonal antibody AC5, prepared using brominated KLH as antigen, indicates predominant reactivity with di-bromo-, di-chloro-, and di-iodo-tyrosine (PMID: 15589368.)

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Lipid Peroxidation

 HEL ELISA



Hexanoyl-lys adduct (HEL), a biomarker of lipid peroxidation and oxidative stress, is formed by reaction of linoleic acid hydroperoxide with lysine. This kit enables the sensitive detection of HEL in animal urine and serum using a well characterized anti-HEL monoclonal antibody. In use, HEL in samples inhibits the binding of anti-HEL to immobilized HEL. Bound anti-HEL is then detected with peroxidase labeled anti-murine Ig antibody.
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Endocrine Research

Human PYY EIA








Peptide YY (PYY) is a gastric peptide hormone that inhibits several gastic functions. Plasma PYY levels decrease after eating. This immunoassay enables the convenient and sensitive quantification of PYY in human plasma, showing essentially no reactivity with the relative NPY peptide. In use, PYY in sample inhibits maximal binding of biotin-PYY to PYY antibody which are quantitated in a color reaction using peroxidase substrate OPD.
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Assay Development 

Polymer Blocking Reagents
 


Unique blocking and stabilizing reagents for assay development with the properties you need: Advanced synthetic polymer free of animal contaminants, efficiently blocks non-specific absorption, intrinsic stabilizing activity for immobilized active proteins, consistent formulation, stable to detergents, heat (autoclavable), freezing, easy to use...and more.
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Purification
 

Magnetic Beads



The Magical Trapper apparatus is a convenient and effective platform for the parallel processing of samples using magnetic bead technology. Firmly holds tubes in place for convenient decanting. Intelligent, light weight design. Use in conjunction with pre-configured MagExtractor reagent sets to improve and simply many types of nucleic acid and protein purification procedures. 
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Neuronal Research  

Anti S14G-Humanin Antibody




When expressed in neurons, the S14G mutant of the neuroprotective 24aa brain polypeptide Humanin was approximately 10 fold more protective against Abeta42 induced cell death than native humanin. This polypeptide antibody reacts preferentially with human S14G-Humanin (PMID: 11371646).

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Totally Unique Transfection Alternative  

GenomOne-Neo



Utilizes the membrane fusion properties of HVJ (Sendai virus) envelope to transfect cells with DNA, RNA or proteins. Over 100 references in vivo and in vitro. Great for  siRNA.
  
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About Cosmo Bio

Cosmo Bio USA is the exclusive US distributor for Cosmo Bio Co., Ltd. (Tokyo), bringing you select reagents and small instruments for life science research from Japan. With well over 1,000 products from more than 40 Japanese manufacturers and academic labs, Cosmo Bio conveniently consolidates a wide range of routine and highly unique biotools including over 1,000 antibodies, ELISA and assay kits, and much more. Many products from Cosmo Bio have previously been unavailable commercially or outside of Japan. 

For over 25 years, Cosmo Bio has been fully committed to exceeding customer expectations by providing quality products and the highest standards of customer care and support. 

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